Observational studyIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Psychiatric comorbidities in patients with inflammatory bowel disease.
Observational study in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Small bowel adenocarcinoma in Crohn's disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes.International journal of colorectal disease · 2022Pooled it
- Feasibility, Acceptability, and Safety of Faecal Microbiota Transplantation in the Treatment of Major Depressive Disorder: A Pilot Randomized Controlled Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Trial
- Health-related quality of life and associated factors in Chinese menstrual migraine patients: a cross-sectional study.BMC women's health · 2022Trial
- Prevalence and Clinical Correlates of Psychiatric Disorders in a Hispanic-Majority Inflammatory Bowel Disease Cohort.Cureus · 2026Article
- Is (critical) health literacy a key to better psychosomatic functioning in patients with inflammatory bowel disease? Testing a mediation model.Frontiers in psychiatry · 2026Article
- From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap.Biology · 2025Article
- Inflammatory bowel disease in south Asia: a scoping review.The lancet. Gastroenterology & hepatology · 2025Article
- Depression and active disease are the major risk factors for fatigue and sleep disturbance in inflammatory bowel disease with consequent poor quality of life: Analysis of the interplay between psychosocial factors from the developing world.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- The Association Between Increased Maladaptive Health Behaviours and Elevated Mental Health Symptoms Among Persons with IBD During the COVID-19 Pandemic.Journal of the Canadian Association of Gastroenterology · 2023Article
- The impact of restrictions on psychological outcomes in patients with inflammatory bowel disease on biological treatment during the coronavirus pandemic in Norway.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice.Biomedicines · 2023Article
- Improving disease management of patients with inflammatory bowel disease: the potential role of self-concordant health goals.Frontiers in psychology · 2023Article
- The relationship of major depressive disorder with Crohn's disease activity.Clinics (Sao Paulo, Brazil) · 2023Article
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications.Frontiers in immunology · 2022Review
- Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD).Molecular psychiatry · 2021Article
- Management of Crohn Disease: A Review.JAMA · 2021Review
- Sleep disturbance in Inflammatory Bowel Disease: prevalence and risk factors - A cross-sectional study.Scientific reports · 2020Article
- Psychiatric morbidity in inflammatory bowel disease: Time to screen all the patients.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychiatric comorbidities are associated with inflammatory bowel disease (IBD). We conducted an observational study to evaluate the prevalence of depression and anxiety in patients with IBD.
methodsSeventy consecutive consenting patients with IBD (62 ulcerative colitis [UC], 8 Crohn's disease [CD]; 40 males, mean age [SD] 36.2 [11.3] years) and 100 healthy volunteers (44 males, age 31.22 [SD] [10.5] years) as controls were enrolled. All participants were directed to take self-assessment tests, Patient Health Questionnaire -9 (PHQ-9) and Symptom Checklist Anxiety Scale (SCL-A20). Participants having a score ≥ 10 on PHQ-9, or ≥ 29 on SCL-A20 were administered the Hamilton Depression Rating Scale (HAM-D) or Hamilton Anxiety (HAM-A) scales, respectively. The severity of depression and anxiety was graded with HAM-D and HAM-A scales, respectively. The protocol was approved by the Institutional Ethics Committee.
resultsThe prevalence of depression (34.3% vs. 5%, p < 0.0001, OR 9.7) and anxiety (18.6% vs. 2%, p = 0.0002, OR 11.17) was higher in patients with IBD as compared to controls. The severity of depression was higher in patients compared to controls (mean rank 17 vs. 7, p = 0.04). The prevalence of depression was not different between UC and CD; all IBD patients with anxiety had UC. The mean duration of disease and history of corticosteroid treatment or surgery for IBD were not associated with the presence of depression or anxiety. Patients with severe CD (Crohn's disease activity index, CDAI > 450) had more severe depression. The severity of UC did not correlate with severity of anxiety or depression in UC.
conclusionsAnxiety and depression are more prevalent in IBD patients as compared to healthy individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.