Evidence map›Paper›PMID 30196472›Full record

ArticleArchivum immunologiae et therapiae experimentalis2019

TLR2 Expression on Leukemic B Cells from Patients with Chronic Lymphocytic Leukemia.

Agata Szymańska, Agnieszka Bojarska-Junak, Arkadiusz Drobiecki, Waldemar Tomczak, Jacek Roliński, Marek Hus, Iwona Hus

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archivum immunologiae et therapiae experimentalis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Agata SzymańskaIndependent Clinical Transplantology Unit, Medical University of Lublin, Lublin, Poland. agata_szymanska@yahoo.com.
Agnieszka Bojarska-JunakDepartment of Clinical Immunology, Medical University of Lublin, Lublin, Poland.
Arkadiusz DrobieckiDepartment of Hematology and Bone Marrow Transplantation, Holy Cross Cancer Center, Kielce, Poland.
Waldemar TomczakDepartment of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.
Jacek RolińskiDepartment of Clinical Immunology, Medical University of Lublin, Lublin, Poland.
Marek HusDepartment of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.
Iwona HusIndependent Clinical Transplantology Unit, Medical University of Lublin, Lublin, Poland.
Medical University of Lublin · PLHoly Cross University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigenic stimulation is considered as a possible trigger of neoplastic transformation in chronic lymphocytic leukemia (CLL). B-cell receptor plays a key role in the interactions between the microenvironment and leukemic cells; however, an important role has also been attributed to Toll-like receptors (TLRs). It is believed that disorders of TLR expression may play a part in the pathogenesis of CLL. In this study, we investigated the potential role of TLR2 in CLL by analyzing its expression on leukemic B cells in correlation with clinical and laboratory parameters characterizing disease activity and patients' immune status. We assessed the frequencies of TLR2

Indexed as

AgedAged, 80 and overAntigens, CD19B-LymphocytesCase-Control StudiesCD5 AntigensChromosome AberrationsFemaleHumansLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedTime FactorsToll-Like Receptor 2Treatment OutcomeZAP-70 Protein-Tyrosine KinaseAntigens, CD19CD19 molecule, humanCD5 AntigensTLR2 protein, humanToll-Like Receptor 2ZAP-70 Protein-Tyrosine KinaseChronic lymphocytic leukemiaPrognostic factorsTLR2 expressionToll-like receptors

Identifiers

PMID30196472
PMCPMC6433797
OpenAlexW2890250608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.