Evidence map›Paper›PMID 30196394›Full record

ArticleMolecular neurobiology2019

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment.

Ghulam Jeelani Pir, Bikash Choudhary, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Eckhard Mandelkow, Eva-Maria Mandelkow, Yipeng Wang

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
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  7. Article
  8. The role of wild-type tau in Alzheimer's disease and related tauopathies.Journal of life sciences (Westlake Village, Calif.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ghulam Jeelani PirGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany. Jeelani.Pir@dzne.de.
Bikash ChoudharyGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.
Senthilvelrajan KaniyappanGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.
Ram Reddy ChandupatlaGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.
Eckhard MandelkowGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.
Eva-Maria MandelkowGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany. Eva.Mandelkow@dzne.de.ORCID http://orcid.org/0000-0002-7715-4038
Yipeng WangGerman Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany. yipeng810@qq.com.
German Center for Neurodegenerative Diseases · DECenter of Advanced European Studies and Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tau aggregation is a hallmark of a group of neurodegenerative diseases termed Tauopathies. Reduction of aggregation-prone Tau has emerged as a promising therapeutic approach. Here, we show that an anti-aggregant Tau fragment (F3

Indexed as

AnimalsCaenorhabditis elegansCell Line, TumorDisease Models, AnimalHumansMiceMicrotubulesMitochondriaModels, BiologicalPeptide FragmentsProtein AggregatesProtein Structure, Secondarytau ProteinsPeptide FragmentsProtein Aggregatestau ProteinsAggregationAlzheimer diseaseCell modelLife-spanMicrotubulesTauTransgenic C.elegansβ-breaker peptides

Identifiers

PMID30196394
PMCPMC6476873
OpenAlexW2890867798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.