ArticlePediatric nephrology (Berlin, Germany)2019
A clinical predictive model of chronic kidney disease in children with posterior urethral valves.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Risk factors for perinatal and neonatal mortality in cases with congenital anomalies of the kidney and urinary tract: a nested cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Management of patients with posterior urethral valves "from the fetus to adolescence": French national diagnostic and care protocol (NDCP).Orphanet journal of rare diseases · 2025Article
- Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.Journal of the American Society of Nephrology : JASN · 2024Article
- Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Congenital anomalies of the kidney and urinary tract: defining risk factors of disease progression and determinants of outcomes.Pediatric nephrology (Berlin, Germany) · 2023Review
- Predicting outcomes in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Nadir creatinine as a predictor of renal outcomes in PUVs: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Chronic Kidney Disease in Boys with Posterior Urethral Valves-Pathogenesis, Prognosis and Management.Biomedicines · 2022Review
- Predicting childhood chronic kidney disease severity in infants with posterior urethral valve: a critical analysis of creatinine values in the first year of life.Pediatric nephrology (Berlin, Germany) · 2022Article
- Posterior urethral valves: Role of prenatal diagnosis and long-term management of bladder function; a single center point of view and review of literature.Frontiers in pediatrics · 2022Review
- Evaluation of polyuria and polydipsia along with other established prognostic factors in posterior urethral valves for progression to kidney failure: experience from a developing country.Pediatric nephrology (Berlin, Germany) · 2021Article
- Predicting outcomes and improving care in children with congenital kidney anomalies.Pediatric nephrology (Berlin, Germany) · 2020Article
- A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis.Clinical kidney journal · 2020Article
- Clinical predictors of chronic kidney disease in congenital lower urinary tract obstruction.Pediatric nephrology (Berlin, Germany) · 2020Review
- Editorial: Developmental Disorders of the Kidney and Urinary Tract: Recent Insights From Clinical and Molecular Studies.Frontiers in pediatrics · 2020Article
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9 authors.
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Abstract
backgroundPosterior urethral valves (PUVs) are associated with severe consequences to the urinary tract and are a common cause of chronic kidney disease (CKD). The aim of this study was to develop clinical predictive model of CKD in a cohort of patients with PUVs.
methodsIn this retrospective cohort study, 173 patients with PUVs were systematically followed up at a single tertiary unit. The primary endpoint was CKD ≥ stage 3. Survival analyses were performed by Cox regression proportional hazard models with time-fixed and time-dependent covariables.
resultsMean follow-up time was 83 months (SD, 70 months). Sixty-five children (37.6%) developed CKD stage ≥ 3. After adjustment by the time-dependent Cox model, baseline creatinine, nadir creatinine, hypertension, and proteinuria remained as predictors of the endpoint. After adjustment by time-fixed model, three variables were predictors of CKD ≥ stage 3: baseline creatinine, nadir creatinine, and proteinuria. The prognostic risk score was divided into three categories: low-risk (69 children, 39.9%), medium-risk (45, 26%), and high-risk (59, 34.1%). The probability of CKD ≥ stage 3 at 10 years age was estimated as 6%, 40%, and 70% for patients assigned to the low-risk, medium-risk, and high-risk groups, respectively (P < 0.001). The main limitation was the preclusion of some relevant variables, especially bladder dysfunction, that might contribute to a more accurate prediction of renal outcome.
conclusionThe model accurately predicts the risk of CKD in PUVs patients. This model could be clinically useful in applying timely intervention and in preventing the impairment of renal function.
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