ReviewPediatric research2018
Neonatal cerebrovascular autoregulation.
Review in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06994494 (Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS), which is not on this map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Brain injury and long-term outcome after neonatal surgery for non-cardiac congenital anomalies.Pediatric research · 2023Pooled it
- Hemodynamic effects of umbilical cord milking versus early cord clamping in nonvigorous intrauterine growth restricted neonates: a randomized controlled trial.European journal of pediatrics · 2026Trial
- The effect of head positioning on brain tissue oxygenation in preterm infants: a randomized clinical trial study.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Impaired Cerebral Autoregulation in Pediatric Patients with ECMO: A Retrospective Analysis of ECMO Time Periods and Association with Neurologic Injury.Neurocritical care · 2026Observational
- Dynamic multimodal brain function monitoring enables quantitative severity grading and prognostic prediction in pediatric neurocritical care.Jornal de pediatria · 2026Article
- Age-dependent cerebral oxygenation and brain injury in pediatric cardiac surgery: vulnerability of infants aged ≤6 months.Journal of intensive care · 2026Article
- Multimodal neuromonitoring modalities of neonatal patients on extracorporeal membrane oxygenation.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Cerebral hemodynamic changes in neonates with different types of patent ductus arteriosus: a study using transcranial Doppler ultrasound.BMC pediatrics · 2026Article
- Intraventricular hemorrhage in extremely low birth weight infants: frequency and duration of impaired cerebrovascular reactivity.Pediatric research · 2026Article
- Inflammatory reprogramming of immature oligodendrocytes perturbs myelination and neurodevelopment in a dual-hit model of preterm brain injury.Brain, behavior, & immunity - health · 2026Article
- Cerebral blood flow alterations in neonates with hyperbilirubinemia: an arterial spin labeling magnetic resonance imaging study.Pediatric radiology · 2026Article
- Bilateral Transcranial Doppler Monitoring During Neonatal Cardiac Surgery; Guidance for Clinical and Scientific Use.Paediatric anaesthesia · 2026Article
- Intra-operative physiologic interventions associated with postoperative neurological complications in neonates and infants: A secondary analysis of the NECTARINE cohort.European journal of anaesthesiology · 2026Article
- Analysis of cerebral hemodynamics in neonates receiving extracorporeal membrane oxygenation support.Italian journal of pediatrics · 2026Article
- Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries.Experimental physiology · 2026Article
- Impact of different hemodynamic states of patent ductus arteriosus on cerebral, mesenteric, and renal perfusion in preterm infants: a doppler ultrasound analysis.BMC pediatrics · 2026Article
- Melatonin Promotes Neurogenesis via the JAK2/STAT3 Pathway in Hypoxic-Ischemic Neonatal Rats.Neurochemical research · 2026Article
- Prediction of acute lung injury/acute respiratory distress syndrome after cardiopulmonary bypass in infants by monitoring femoral oxygen saturation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Cerebrovascular pressure autoregulation is the physiologic mechanism that holds cerebral blood flow (CBF) relatively constant across changes in cerebral perfusion pressure (CPP). Cerebral vasoreactivity refers to the vasoconstriction and vasodilation that occur during fluctuations in arterial blood pressure (ABP) to maintain autoregulation. These are vital protective mechanisms of the brain. Impairments in pressure autoregulation increase the risk of brain injury and persistent neurologic disability. Autoregulation may be impaired during various neonatal disease states including prematurity, hypoxic-ischemic encephalopathy (HIE), intraventricular hemorrhage, congenital cardiac disease, and infants requiring extracorporeal membrane oxygenation (ECMO). Because infants are exquisitely sensitive to changes in cerebral blood flow (CBF), both hypoperfusion and hyperperfusion can cause significant neurologic injury. We will review neonatal pressure autoregulation and autoregulation monitoring techniques with a focus on brain protection. Current clinical therapies have failed to fully prevent permanent brain injuries in neonates. Adjuvant treatments that support and optimize autoregulation may improve neurologic outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.