ArticleGerontology2019
Blood-Based Therapies to Combat Aging.
Article in Gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice.Nature communications · 2026Article
- Plasma-based strategies for systemic rejuvenation: critical perspectives on clinical translation.GeroScience · 2026Review
- Porcine plasma-derived extracellular vesicles orchestrate multi-target neuroimmune reconfiguration to alleviate Alzheimer's disease pathology in a 5×FAD mouse model.Journal of neuroinflammation · 2026Article
- Brain-rejuvenating factor TIMP2 is associated with brain health and neuroprotective lifestyle in aged subjects.medRxiv : the preprint server for health sciences · 2025Article
- Plasma therapy: a novel intervention to improve age-induced decline in deudenal cell proliferation in female rat model.Biogerontology · 2025Article
- APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.Annals of clinical and translational neurology · 2025Article
- Toward precision longevity: aging interventions in the single-cell atlas era.Frontiers in aging · 2025Review
- Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer's Disease.Cellular and molecular neurobiology · 2024Review
- Cell senescence in cardiometabolic diseases.npj aging · 2024Review
- Blood-based therapies to combat neurodegenerative diseases.Metabolic brain disease · 2024Review
- Supplementing probiotics during intermittent fasting proves more effective in restoring ileum and colon tissues in aged rats.Journal of cellular and molecular medicine · 2024Article
- scDiffCom: a tool for differential analysis of cell-cell interactions provides a mouse atlas of aging changes in intercellular communication.Nature aging · 2023Article
- Partial blood replacement ameliorates middle cerebral artery occlusion generated neurological aberrations by intervening TLR4 and NLRP3 cascades in rats.Metabolic brain disease · 2023Article
- The rejuvenating influence of young plasma on aged intestine.Journal of cellular and molecular medicine · 2023Article
- Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses.Biogerontology · 2023Article
- The effect of young blood plasma administration on gut microbiota in middle-aged rats.Archives of microbiology · 2022Article
- Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response.Aging and disease · 2022Article
- Review
- Acceleration of Biological Aging and Underestimation of Subjective Age Are Risk Factors for Severe COVID-19.Biomedicines · 2021Article
- Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?Biomedicines · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting health-care costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzhei-mer's disease. As the proportion of aged individuals continues to rise in the coming decades, aging-related costs are expected to increase dramatically. Diverse approaches have emerged to meet the clinical need to treat aging and its associated conditions, including those aimed at increasing longevity, slowing the aging process itself, and improving healthspan. An emerging approach takes advantage of molecules circulating in the blood to limit or reverse aspects of aging in various organs throughout the body. Efforts are underway to translate these findings into novel therapeutics that harness the activity of youth-associated molecules present within blood. Here, we discuss the current state of blood-based approaches in this arena. Despite the apparent ease with which blood products might conceivably be applied as treatment paradigms, we propose that challenges nonetheless exist, which may be overcome with mechanistic studies that identify common pathways for targeted therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.