Evidence map›Paper›PMID 30196280›Full record

ArticleStereotactic and functional neurosurgery2018

Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation.

Mahsa Malekmohammadi, Hiro Sparks, Nicholas AuYong, Andrew Hudson, Nader Pouratian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stereotactic and functional neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahsa MalekmohammadiDepartment of Neurosurgery, University of California, Los Angeles, California, USA.
Hiro SparksDepartment of Neurosurgery, University of California, Los Angeles, California, USA.
Nicholas AuYongDepartment of Neurosurgery, University of California, Los Angeles, California, USA.
Andrew HudsonDepartment of Anesthesiology, University of California, Los Angeles, California, USA.
Nader PouratianDepartment of Neurosurgery, University of California, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

The Pathophysiology of Network Synchrony in Parkinson's DiseaseR01NS097782 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI NADER POURATIAN · 2016 to 2026
$5.2M
UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
Electrophysiologic and Anatomic Basis of BOLD fMRIK23EB014326 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI POURATIAN, NADER · 2012 to 2016
$946k
Network perturbations: specificity of general anesthetic actions on interneuron subpopulationsK08GM121961 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUDSON, ANDREW · 2016 to 2019
$771k
NIBIB NIH HHS K23 EB014326NIGMS NIH HHS K08 GM121961NINDS NIH HHS R01 NS097782NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

BACKGROUND/

aimsThere are reports that microelectrode recording (MER) can be performed under certain anesthetized conditions for functional confirmation of the optimal deep brain stimulation (DBS) target. However, it is generally accepted that anesthesia affects MER. Due to a potential role of local field potentials (LFPs) in DBS functional mapping, we characterized the effect of propofol on globus pallidus interna (GPi) and externa (GPe) LFPs in Parkinson disease (PD) patients.

methodsWe collected LFPs in 12 awake and anesthetized PD patients undergoing DBS implantation. Spectral power of β (13-35 Hz) and high-frequency oscillations (HFOs: 200-300 Hz) was compared across the pallidum.

resultsPropofol suppressed GPi power by > 20 Hz while increasing power at lower frequencies. A similar power shift was observed in GPe; however, power in the high β range (20-35 Hz) increased with propofol. Before anesthesia both β and HFO activity were significantly greater at the GPi (χ2 = 20.63 and χ2 = 48.81, p < 0.0001). However, during anesthesia, we found no significant difference across the pallidum (χ2 = 0.47, p = 0.79, and χ2 = 4.11, p = 0.12).

conclusionGPi and GPe are distinguishable using LFP spectral profiles in the awake condition. Propofol obliterates this spectral differentiation. Therefore, LFP spectra cannot be relied upon in the propofol-anesthetized state for functional mapping during DBS implantation.

Indexed as

AgedAnesthesiaAnesthetics, IntravenousBrain MappingDeep Brain StimulationFemaleGlobus PallidusHumansMaleMicroelectrodesMiddle AgedParkinson DiseasePropofolAnesthetics, IntravenousPropofolDeep brain stimulationFunctional mappingGeneral anesthesiaGlobus pallidusLocal field potentialsPropofol

Identifiers

PMID30196280
PMCPMC6550291
OpenAlexW2891656577

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.