Evidence map›Paper›PMID 30196160›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2019

Influence of Early Life, Diet, and the Environment on the Microbiome.

Tien S Dong, Arpana Gupta

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
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  5. Breastfeeding and the Risk of Infant Illness in Asia: A Review.International journal of environmental research and public health · 2019
    Pooled it
  6. Trial
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  8. Review
  9. The gut microbiota in malnutrition.Nature reviews. Microbiology · 2026
    Review
  10. Article
  11. Review
  12. Review
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  14. Article
  15. Maintaining microbiota across diverse symbiotic organs inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Review
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  18. Article
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tien S DongVatche and Tamar Manoukin Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Arpana GuptaVatche and Tamar Manoukin Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, Los Angeles, California. Electronic address: agupta@mednet.ucla.edu.

Funding

GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
NIDDK NIH HHS K23 DK106528NIDDK NIH HHS R03 DK121025NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

Advances in sequencing technology and bioinformatics have greatly enhanced our ability to understand the human microbiome. Over the last decade, a growing body of literature has linked nutrition and the environment to the microbiome and is now thought to be an important contributor to overall health. This paper reviews the literature from the past 10 years to highlight the influence of environmental factors such as diet, early life adversity and stress in shaping and modifying our microbiome towards health and disease. The review shows that many factors such as the mode of delivery, breast milk, stress, diet and medications can greatly influence the development of our gut microbiome and potentially make us more prone to certain diseases. By incorporating environmental factors into models that study the microbiome in the setting of health and disease, may provide a better understanding of disease and potentially new areas of treatment. To highlight this, we will additionally explore the role of the environment and the microbiome in the development of obesity and functional bowel disorders.

Indexed as

Environmental ExposureGastrointestinal MicrobiomeHost Microbial InteractionsMicrobiotaDietHumansInfantInfant, NewbornEarly Life DietEnvironmentGut MicrobiomeIrritable Bowel SyndromeObesityStress

Identifiers

PMID30196160
PMCPMC6422042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.