ArticleBiophysical journal2018
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Cytoplasmic abundant heat-soluble proteins from tardigrades protect synthetic cells under stress.Nature communications · 2026Article
- A phase transition modulates the protective function of a tardigrade disordered protein during desiccation.Protein science : a publication of the Protein Society · 2025Article
- LEA proteins and ABA signaling: reciprocal regulation in stress adaptation.Frontiers in plant science · 2025Review
- Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties.PNAS nexus · 2024Article
- Low-temperature and circadian signals are integrated by the sigma factor SIG5.Nature plants · 2023Article
- Large-scale comparative transcriptomic analysis of temperature-responsive genes in Arabidopsis thaliana.Plant molecular biology · 2022Article
- Specialty grand challenge in plant biophysics and modeling.Frontiers in plant science · 2022Article
- Lipid/water interface of galactolipid bilayers in different lyotropic liquid-crystalline phases.Frontiers in molecular biosciences · 2022Article
- Advances in Understanding of Desiccation Tolerance of Lichens and Lichen-Forming Algae.Plants (Basel, Switzerland) · 2021Review
- Lipid Remodeling Confers Osmotic Stress Tolerance to Embryogenic Cells during Cryopreservation.International journal of molecular sciences · 2021Article
- The biology of tardigrade disordered proteins in extreme stress tolerance.Cell communication and signaling : CCS · 2020Review
- The plant dehydrin Lti30 stabilizes lipid lamellar structures in varying hydration conditions.Journal of lipid research · 2020Article
- Similar Yet Different-Structural and Functional Diversity amongInternational journal of molecular sciences · 2020Article
- Structural properties and cellular expression of AfrLEA6, a group 6 late embryogenesis abundant protein from embryos of Artemia franciscana.Cell stress & chaperones · 2019Article
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants from temperate climates, such as the model plant Arabidopsis thaliana, are challenged with seasonal low temperatures that lead to increased freezing tolerance in fall in a process termed cold acclimation. Among other adaptations, this involves the accumulation of cold-regulated (COR) proteins, such as the intrinsically disordered chloroplast-localized protein COR15A. Together with its close homolog COR15B, it stabilizes chloroplast membranes during freezing. COR15A folds into amphipathic α-helices in the presence of high concentrations of low-molecular-mass crowders or upon dehydration. Under these conditions, the (partially) folded protein binds peripherally to membranes. In our study, we have used coarse-grained molecular dynamics simulations to elucidate the details of COR15A-membrane binding and its effects on membrane structure and dynamics. Simulation results indicate that at least partial folding of COR15A and the presence of highly unsaturated galactolipids in the membranes are necessary for efficient membrane binding. The bound protein is stabilized on the membrane by interactions of charged and polar amino acids with galactolipid headgroups and by interactions of hydrophobic amino acids with the upper part of the fatty acyl chains. Experimentally, the presence of liposomes made from a mixture of lipids mimicking chloroplast membranes induces additional folding in COR15A under conditions of partial dehydration, in agreement with the simulation results.
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