ArticlePsychiatry research2018
Increased circulating regulatory T cells in medicated people with schizophrenia.
Article in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Randomized double-blind inpatient study of a gluten-free diet for negative symptoms in people with schizophrenia.Schizophrenia research · 2026Trial
- T cells are associated with negative symptoms in persons with anti-gliadin antibody positive schizophrenia and related disorders.Schizophrenia research · 2025Article
- Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis.Molecular neurobiology · 2025Article
- The Correlation of Blood Immune Cells with the Pathogenesis of Schizophrenia: A Meta-Analysis.Iranian journal of public health · 2025Review
- Identification of Immune-Related Biomarkers of Schizophrenia in the Central Nervous System Using Bioinformatic Methods and Machine Learning Algorithms.Molecular neurobiology · 2025Article
- The role of the immune system in early-onset schizophrenia: identifying immune characteristic genes and cells from peripheral blood.BMC immunology · 2024Article
- Review
- Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.BMC psychiatry · 2023Article
- Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides.Neural regeneration research · 2023Review
- Neuroimmune, clinical and treatment challenges in multiple sclerosis-related psychoses.World journal of psychiatry · 2023Review
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Changes in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study.Neuropsychiatric disease and treatment · 2023Article
- Article
- Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance.Frontiers in systems neuroscience · 2022Article
- Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics.Frontiers in pharmacology · 2022Article
- Identification of hub genes and construction of diagnostic nomogram model in schizophrenia.Frontiers in aging neuroscience · 2022Article
- T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives.Brain, behavior, & immunity - health · 2021Article
- Common and disorder-specific upregulation of the inflammatory markers TRAIL and CCL20 in depression and schizophrenia.Scientific reports · 2021Observational
- Increased random exploration in schizophrenia is associated with inflammation.NPJ schizophrenia · 2021Article
- Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Immunological abnormalities are increasingly reported in people with schizophrenia, but no clear functional biomarkers associated with genetic correlates of the disease have been found. Regulatory T cells (Tregs) are key immunoregulatory cells involved in the control of inflammatory processes and their functions are directly related to the human leucocyte antigen (HLA) gene, which has been implicated in schizophrenia genetic studies. However, there is a lack of studies reporting Treg status in people with schizophrenia. In the current study, the proportion of circulating Tregs was examined using flow cytometry in 26 medicated participants with schizophrenia and 17 healthy controls. Psychiatric symptoms and cognitive function were evaluated using the Scale for the Assessment of Negative Symptoms, the Brief Psychiatric Rating Scale, and the MATRICS Consensus Cognitive Battery. The proportion of Tregs was found to be significantly greater in the schizophrenia group compared to healthy controls. No differences were observed in total lymphocyte counts or CD3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.