Evidence map›Paper›PMID 30195191›Full record

ArticleRedox biology2018

Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca

Dan Wu, Qingxun Hu, Bo Tan, Peter Rose, Deqiu Zhu, Yi Zhun Zhu

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Dan WuDepartment of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Qingxun HuMitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, USA.
Bo TanSchool of Pharmacy, Fudan University, Shanghai, China.
Peter RoseSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
Deqiu ZhuDepartment of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: zdq_0726@163.com.
Yi Zhun ZhuSchool of Pharmacy, Macau University of Science and Technology, Macau, China; School of Pharmacy, Fudan University, Shanghai, China. Electronic address: yzzhu@must.edu.mo.
Tongji University · CNFudan University · CNMacau University of Science and Technology · MOUniversity of Nottingham · GBUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCa

resultsTreatment with S-propyl-L-cysteine (SPRC) or sodium hydrosulfide (NaHS), modulators of blood H INNOVATION AND

conclusionsA novel mechanism depicting a role of S-sulfhydration in the regulation of CaMKII is presented. SPRC mediated S-sulfhydration of CaMKII was found to inhibit CAMKII activity and to preserve cardiovascular homeostasis.

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell LineCystathionine gamma-LyaseEnzyme ActivationHeart FailureHydrogen SulfideMaleMiceMice, Inbred C57BLMice, KnockoutMitochondria, HeartMyocytes, CardiacPhosphorylationSignal TransductionCalcium-Calmodulin-Dependent Protein Kinase Type 2Cystathionine gamma-LyaseHydrogen SulfideCa(2+)/calmodulin-dependent protein kinase IIHeart FailureHydrogen SulfideMitochondriaS-sulfhydration

Identifiers

PMID30195191
PMCPMC6128039
OpenAlexW2888580420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.