ArticleJournal of psychiatric research2018
Assessment of neuroplasticity in late-life depression with transcranial magnetic stimulation.
Article in Journal of psychiatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis.Psychological medicine · 2021Pooled it
- Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Developmental lead (pb) exposure induces anxiety and depression-like behaviorsCurrent research in toxicology · 2026Article
- Mental Health and Aging: Identifying Risk and Protective Factors of Anxiety and Depression in Older Women.Aging medicine (Milton (N.S.W)) · 2025Article
- Efficacy and Safety of Transcranial Magnetic Stimulation for Treating Late-Life Depression: A Scoping Review.Journal of clinical medicine · 2025Review
- A new index of cortical plasticity induced by paired associative stimulation to describe cognitive status in aged healthy subjects.Frontiers in physiology · 2025Article
- Devices and Technology in Transcranial Magnetic Stimulation: A Systematic Review.Brain sciences · 2022Review
- An inverse relationship between cortical plasticity and cognitive inhibition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundStudies using Transcranial Magnetic Stimulation (TMS), a non-invasive method of brain stimulation, have implicated impaired neuroplasticity in the pathophysiology of depression in younger adults. The role of neuroplasticity in late-life depression (LLD) has not yet been explored using TMS.
objectiveThis study aimed at evaluating motor cortical neuroplasticity using paired associative stimulation (PAS). Single-pulse TMS was used to induce motor-evoked potentials (MEP) in the contralateral hand muscle before and after PAS. The potentiation of MEP amplitudes after PAS was used as an indirect index of associative plasticity and long-term potentiation (LTP) (i.e. PAS-LTP).
results48 older adults with depression and 34 age-matched healthy controls (HC) were compared. PAS- LTP was successfully induced in 68.8% of older adults with depression and 47.1% of HC. At the group level, older adults with depression failed to show statistically significant induction of neuroplasticity, which was observed in HC. However, no significant differences were observed between the two groups for PAS-LTP.
conclusionOur results suggest that associative plasticity does not differ substantially between older adults with depression and age-matched HC. Continued research is needed to more comprehensively understand the role of neuroplasticity in the pathophysiology of LLD.
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Registered trials
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