Evidence map›Paper›PMID 30195042›Full record

ArticleToxicology in vitro : an international journal published in association with BIBRA2019

Antioxidant and pro-oxidant mechanisms of (+) catechin in microsomal CYP2E1-dependent oxidative stress.

Andres A Caro, Alanna Davis, Sydney Fobare, Nicholas Horan, Cameron Ryan, Cara Schwab

Open access · greenAbstract read
In one paragraph

Article in Toxicology in vitro : an international journal published in association with BIBRA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 52 citations in OpenAlex.

  1. Characterization ofMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Investigating the Osteoregenerative Properties ofJournal of functional biomaterials · 2025
    Article
  4. Article
  5. Article
  6. Biology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Chemical Components and Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Review
  13. In Vitro Antioxidant and Anticancer Properties of VariousMolecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Fucoidan Extracted From Sporophyll ofFrontiers in nutrition · 2021
    Article
  16. Screening ofFrontiers in bioengineering and biotechnology · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andres A CaroChemistry Department, Hendrix College, Conway, AR 72032, United States. Electronic address: caro@hendrix.edu.
Alanna DavisChemistry Department, Hendrix College, Conway, AR 72032, United States.
Sydney FobareChemistry Department, Hendrix College, Conway, AR 72032, United States.
Nicholas HoranChemistry Department, Hendrix College, Conway, AR 72032, United States.
Cameron RyanChemistry Department, Hendrix College, Conway, AR 72032, United States.
Cara SchwabChemistry Department, Hendrix College, Conway, AR 72032, United States.
Conway School of Landscape Design · USHendrix College · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

The objectives of this work were to evaluate the effects of catechin on cytochrome P450 2E1 (CYP2E1)-dependent oxidative stress. Microsomes co-expressing human CYP2E1 with NADPH cytochrome P450 reductase and cytochrome b5 were incubated with NADPH and DTPA at pH 7.0. Superoxide anion generation was specifically detected by spin-trapping with DEPMPO. Generation of the DEPMPO-OOH adduct was not observed in the absence of CYP2E1 and in the presence of superoxide dismutase (SOD) or catechin, while catalase was ineffective. Reactive oxygen species generation was detected with 1-hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine (CPH) by the EPR-detection of its oxidation product, 3-carboxy-proxyl radical (CP

Indexed as

AntioxidantsCatechinCytochrome P-450 CYP2E1MicrosomesOxidantsOxidation-ReductionOxidative StressReactive Oxygen SpeciesAntioxidantsCatechinCytochrome P-450 CYP2E1OxidantsReactive Oxygen SpeciesAntioxidantCatechinCYP2E1MicrosomesOxidative stressReactive oxygen species

Identifiers

PMID30195042
PMCPMC6281780
OpenAlexW2890044474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.