Evidence map›Paper›PMID 30194988›Full record

ArticleThe Journal of allergy and clinical immunology2019

Paraben exposures and asthma-related outcomes among children from the US general population.

Lesliam Quirós-Alcalá, Nadia N Hansel, Meredith C McCormack, Elizabeth C Matsui

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
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  14. Article
  15. Effect of triclosan on the pathogenesis of allergic diseases among children.Journal of exposure science & environmental epidemiology · 2022
    Article
  16. Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens.International journal of environmental research and public health · 2021
    Article
  17. Article
  18. Review
  19. Review
  20. Respiratory Failure after the Use of a New Hair Spray.Internal medicine (Tokyo, Japan) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lesliam Quirós-AlcaláMaryland Institute of Applied Environmental Health, School of Public Health, University of Maryland, College Park, Md. Electronic address: lquiros@umd.edu.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Md; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Meredith C McCormackDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Md; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Elizabeth C MatsuiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Md; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.

Funding

The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority childrenR01ES026170 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI KEET, CORINNE, MATSUI, ELIZABETH C. · 2016 to 2025
$6.8M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Jennifer L Glass · 2017 to 2026
$5.2M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
The Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2015 to 2019
$3.5M
Environmental Control as Add-on Therapy in Urban Children with AsthmaR01ES023447 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2014 to 2018
$3.4M
Clinical trial of air cleaners to improve indoor air quality and COPD healthR01ES022607 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2013 to 2017
$3.4M
SPIROMICS - Air Pollution StudyR01ES023500 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N, KAUFMAN, JOEL DANIEL · 2014 to 2018
$3.2M
Mentoring in Patient-Oriented Research on Asthma and the Indoor EnvironmentK24AI114769 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MATSUI, ELIZABETH C. · 2015 to 2023
$1.6M
Antimicrobial Agents and Asthma Morbidity among African American Children withAsthmaK01HL138124 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI QUIROS-ALCALA, LESLIAM · 2017 to 2021
$666k
Clean Air- Heart: Clinical trial of an air purifier intervention to reduce indoor particulate matter and improve cardiovascular outcomes in COPDR21ES025840 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI MCCORMACK, MEREDITH C · 2015 to 2016
$446k
NHLBI NIH HHS K01 HL138124NIAID NIH HHS K24 AI114769NICHD NIH HHS P2C HD042849NIEHS NIH HHS P50 ES018176NIEHS NIH HHS R01 ES022607NIEHS NIH HHS R01 ES023447NIEHS NIH HHS R01 ES023500NIEHS NIH HHS R01 ES026170NIEHS NIH HHS R21 ES025840NIMHD NIH HHS P50 MD010431
6 · The paper itself

Abstract

backgroundParabens are synthetic preservatives present in many consumer products. Their antimicrobial and endocrine-disrupting properties have raised concerns that they might play a role in respiratory and allergic diseases; however, studies exploring these associations are scarce.

objectiveWe examined the cross-sectional association between parabens and asthma morbidity among 450 children with asthma and with asthma prevalence among 4023 children in the US general population participating in the National Health and Nutrition Examination Survey (2005-2014).

methodsWe conducted multivariable logistic regression to examine associations between urinary paraben biomarker concentrations (butyl paraben, ethyl paraben, methyl paraben [MP], and propyl paraben [PP]) and asthma attacks and emergency department visits among children with asthma and with a current asthma diagnosis among all children. We also examined heterogeneity of associations by sex.

resultsWe observed an increased prevalence odds of reporting emergency department visits for every 10-fold increase in MP and PP concentrations among boys with asthma (adjusted prevalence odds ratio, 2.61 [95% CI, 1.40-4.85] and 2.18 [95% CI, 1.22-3.89, respectively; P

conclusionWe identified differential effects of exposure to select parabens by sex on asthma morbidity. Further studies are needed to replicate these findings and elucidate mechanisms by which parabens could affect respiratory health and elicit dimorphic effects by sex.

Indexed as

AdolescentAdultAnti-Infective AgentsAsthmaChildEmergency Service, HospitalEndocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleParabensPrevalenceSex CharacteristicsUnited StatesAnti-Infective AgentsEndocrine DisruptorsEnvironmental PollutantsParabensantimicrobialsasthmachildrenendocrine disruptorsParabensrespiratory

Identifiers

PMID30194988
PMCPMC6691726

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.