ArticleMagnetic resonance in medicine2019
Brain active transmembrane water cycling measured by MR is associated with neuronal activity.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Steady-state water exchange in neural tissue is primarily passive and through the phospholipid bilayer.bioRxiv : the preprint server for biology · 2026Article
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.Magnetic resonance letters · 2026Article
- Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.Magma (New York, N.Y.) · 2026Article
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.bioRxiv : the preprint server for biology · 2025Article
- Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient.The Journal of membrane biology · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- A Futile Cycle?: Tissue Homeostatic Trans-Membrane Water Co-Transport: Kinetics, Thermodynamics, Metabolic Consequences.bioRxiv : the preprint server for biology · 2024Article
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- Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas.Nature biomedical engineering · 2023Article
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- Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange.NeuroImage · 2022Article
- Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopy.NeuroImage · 2020Article
- Real-time measurement of diffusion exchange rate in biological tissue.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Article
- NMR shutter-speed elucidates apparent population inversion ofMagnetic resonance in medicine · 2019Article
- Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry.Angewandte Chemie (International ed. in English) · 2018Article
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4 authors.
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Abstract
purposefMRI is widely used to study brain activity. Unfortunately, conventional fMRI methods assess neuronal activity only indirectly, through hemodynamic coupling. Here, we show that active, steady-state transmembrane water cycling (AWC) could serve as a basis for a potential fMRI mechanism for direct neuronal activity detection.
methodsAWC and neuronal actitivity in rat organotypic cortical cultures were simultaneously measured with a hybrid MR-fluorescence system. Perfusion with a paramagnetic MRI contrast agent, Gadoteridol, allows NMR determination of the kinetics of transcytolemmal water exchange. Changes in intracellular calcium concentration, [Ca
resultsWhen we alter neuronal activity by titrating with extracellular [K
conclusionsThese results suggest that AWC is associated with neuronal activity and NKA activity is a major contributor in coupling AWC to neuronal activity. Although AWC comprises steady-state, homeostatic transmembrane water exchange, our analysis also yields a simultaneous measure of the average cell volume, which reports any slower net transmembrane water transport.
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