ArticleEvolution; international journal of organic evolution2018
A two-locus hybrid incompatibility is widespread, polymorphic, and active in natural populations of Mimulus.
Article in Evolution; international journal of organic evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 55 citations in OpenAlex.
- On the Causes of Correlated Genomic Ancestry Across Contrasting Hybridization Histories in a Monkeyflower Species Pair.Molecular ecology · 2026Article
- On the causes of correlated genomic ancestry across contrasting hybridization histories in a monkeyflower species pair.bioRxiv : the preprint server for biology · 2026Article
- How population subsampling to concentrate selection effects can help to find epistatic interactions of transmission ratio distortion.Heredity · 2026Article
- Introgression and parental conflict shape repeated occurrences of postzygotic isolation in Mimulus.Current biology : CB · 2026Article
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Comparative Genomics of the Testacea Group of Drosophila Reveals Introgression and Variation in Chromosome Size and Structure.Genome biology and evolution · 2025Article
- Admixture Mapping Reveals Evidence for Multiple Mitonuclear Incompatibilities in Swordtail Fish Hybrids.Molecular ecology · 2025Article
- Introgression and Parental Conflict Shape Repeated Occurrences of Postzygotic Isolation.bioRxiv : the preprint server for biology · 2025Article
- Fluctuating reproductive isolation and stable ancestry structure in a fine-scaled mosaic of hybridizing Mimulus monkeyflowers.PLoS genetics · 2025Article
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- Genetic Cause of Hybrid Lethality Observed in Reciprocal Interspecific Crosses betweenInternational journal of molecular sciences · 2024Article
- Strong postmating reproductive isolation in Mimulus section Eunanus.Journal of evolutionary biology · 2023Article
- Hybrid breakdown in male reproduction between recently diverged Drosophila melanogaster populations has a complex and variable genetic architecture.Evolution; international journal of organic evolution · 2023Article
- Intraspecific variation in reproductive barriers between two closely related Arabidopsis sister species.Journal of evolutionary biology · 2023Article
- Patterns of Population Structure and Introgression Among Recently Differentiated Drosophila melanogaster Populations.Molecular biology and evolution · 2022Article
- On the impermanence of species: The collapse of genetic incompatibilities in hybridizing populations.Evolution; international journal of organic evolution · 2022Article
- The strength of reproductive isolating barriers in seed plants: Insights from studies quantifying premating and postmating reproductive barriers over the past 15 years.Evolution; international journal of organic evolution · 2022Article
- Hybrid breakdown is elevated near the historical cores of a species' range.Proceedings. Biological sciences · 2022Article
- Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids.G3 (Bethesda, Md.) · 2022Article
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2 authors at 2 institutions in 2 countries.
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Abstract
Reproductive isolation, which is essential for the maintenance of species in sympatry, is often incomplete between closely related species. In these taxa, reproductive barriers must evolve within species, without being degraded by ongoing gene flow. To better understand this dynamic, we investigated the frequency and geographic distribution of alleles underlying a two-locus, hybrid lethality system between naturally hybridizing species of monkeyflower (Mimulus guttatus and M. nasutus). We found that M. guttatus typically carries hybrid lethality alleles at one locus (hl13) and M. nasutus typically carries hybrid lethality alleles at the other locus (hl14). As a result, natural hybrids carry incompatible alleles at both loci, and express hybrid lethality in later generations. We also discovered considerable polymorphism at both hl13 and hl14 within both species. For M. guttatus, polymorphism at both loci occurs within populations, meaning that incompatible allele pairings likely arise through intraspecific gene flow. Genetic variation at markers linked to hl13 and hl14 suggest that introgression from M. nasutus is the primary driver of this polymorphism within M. guttatus. Additionally, patterns of introgression at the two hybrid lethality loci suggest that natural selection eliminates incompatible allele pairings, suggesting that even weak reproductive barriers might promote genomic divergence between species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.