Evidence map›Paper›PMID 30194626›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

Health-related quality of life (HRQoL) in beta-thalassemia major (β-TM) patients assessed by 36-item short form health survey (SF-36): a meta-analysis.

Mahdieh Arian, Majid Mirmohammadkhani, Raheb Ghorbani, Mohsen Soleimani

3 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05496764 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

The Therapeutic Effect and Quality of Life After Local Injection of Steroid VS. Glucose 5% for Carpal Tunnel Syndrome : Double-blinded Clinical Trial

TypeinterventionalSponsorAssiut UniversityRan2021 to 2023Enrolled52ConditionsCarpal Tunnel SyndromeArmsDexamethasone, Glucose Injection
NCT06606886 phase4completednot on this mapstarted 2024, after this paper: background citation

Effects of Hydroxyurea and Metformin in Transfusion Dependent Beta-Thalassemia

TypeinterventionalSponsorBahria UniversityRan2024 to 2026Enrolled96ConditionsTransfusion Dependent Beta-thalassemiaArmsTablet Metformin (Group A), Tablet Hydroxyurea (Group B)
NCT07352878 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Quality of Life in Patients With Chronic Iron Overload Due to Hemoglobinopathies in Greece, Who Are Under Treatment With Deferasirox, Based on Standard Clinical Practice.

TypeobservationalSponsorElpen Pharmaceutical Co. Inc.Ran2026 to 2027Enrolled150ConditionsThalassemia, Iron Overload
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Reducing waste in collection of quality-of-life data through better reporting: a case study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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  6. Trial
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  11. Humanistic and economic burden among caregivers of adults and children with transfusion dependent β-thalassemia: a mixed-methods study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  12. Review
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  14. Association of healthy eating behaviours and comorbidity on quality of life among adults with beta-thalassemia major: a moderation analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mahdieh ArianStudent Research Committee, Faculty of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran.ORCID http://orcid.org/0000-0001-8481-4914
Majid MirmohammadkhaniSocial Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Raheb GhorbaniSocial Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Mohsen SoleimaniNursing Care Research Center, Nursing and Midwifery Faculty, Semnan University of Medical Sciences, Semnan, Iran. soli257@yahoo.com.

Funding

semnan university of medical sciences IR.SEMUMS.REC.1396.153
6 · The paper itself

Abstract

purposeThe main purpose of this meta-analysis was to evaluate the impact of beta-thalassemia major (BTM) on the health-related quality of life as assessed by the medical outcomes short-form-36 questionnaire (SF-36).

methodsA systematic literature search was performed on Cochrane library, Web of Science, Scopus, Science Direct, ProQues, Medline/PubMed, Scholar Google until March 17, 2017 to obtain eligible studies. A fixed effect model was applied to summarize the scores of each domain. The radar chart was used to compare the scores of BTM patients with other health conditions. Spearman's correlation analysis and meta-regression were used to explore the related factors.

results26 studies were included in this study, which were all reliable to summarize the scores of the SF36. Pooled mean scores of the physical health domains ranged from 52.74 to 74.5, with the GH and PF domains being the lowest and the highest, respectively. Further, the pooled mean scores of the mental health domains varied between 59.6 and 71.11, with the (MH-VT) and SF domains being the maximum and the minimum, respectively. Patients with BTM had a substantially compromised HRQoL in comparison with the general population.

conclusionBTM could adversely affect the HRQoL of patients. Measuring HRQoL should be considered as an essential part of the overall assessment of health status of BTM patients, which would provide valuable clues for improving the management of disease and making decisions on the treatment.

Indexed as

AdolescentAdultbeta-ThalassemiaFemaleHealth SurveysHumansMaleQuality of LifeSurveys and QuestionnairesYoung AdultBeta-thalassemia majorHealth-related quality of lifeMedical outcomes short-form-36 questionnaireMeta-analysisSF-36

Identifiers

PMID30194626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.