Evidence map›Paper›PMID 30194618›Full record

ArticleJournal of assisted reproduction and genetics2018

Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome.

Mindy S Christianson, Richard S Legro, Susan Jin, Esther Eisenberg, Michael P Diamond, Karl R Hansen, Wendy Vitek, Aaron K Styer, Peter Casson, Christos Coutifaris and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Mindy S ChristiansonDepartment of Gynecology and Obstetrics, Division of Reproductive Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mchris21@jhmi.edu.ORCID http://orcid.org/0000-0001-6749-2773
Richard S LegroDepartment of Ob/Gyn, Penn State College of Medicine, Hershey, PA, USA.
Susan JinDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Esther EisenbergEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Michael P DiamondDepartment of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA, USA.
Karl R HansenDepartment of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Wendy VitekDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine, Rochester, NY, USA.
Aaron K StyerDepartment of Obstetrics, Gynecologyn, and Reproductive Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Peter CassonDepartment of Obstetrics and Gynecology, University of Vermont, Burlington, VT, USA.
Christos CoutifarisDepartment of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
Gregory M ChristmanDepartment of Obstetrics and Gynecology, Shands Hospital, University of Florida, Gainesville, FL, USA.
Ruben AlveroDepartment of Obstetrics and Gynecology, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Elizabeth E PuscheckDepartment of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
Alicia Y ChristyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Fangbai SunDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Heping ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.
Alex J PolotskyDepartment of Obstetrics and Gynecology, University of Colorado, Aurora, CO, USA.
Nanette SantoroDepartment of Obstetrics and Gynecology, University of Colorado, Aurora, CO, USA.
Yale University · USNational Institutes of Health · USUniversity of Colorado Anschutz Medical Campus · USAugusta University · USBrown University · USHarvard University · USJohns Hopkins University · USPenn State Milton S. Hershey Medical Center · USUF Health Shands Hospital · USUniversity of Oklahoma Health Sciences Center · USUniversity of Pennsylvania · USUniversity of Rochester · USUniversity of Vermont · USWayne State University · US

Funding

COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKU10HD027049 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 1990 to 2017
$5.2M
Luteal Progesterone Supplementation in Clomiphene Citrate-IUI CyclesU10HD077680 · NICHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HANSEN, KARL RICHARD · 2013 to 2017
$1.5M
Clinical Research Scientist Program (CREST) R25HD075737NICHD NIH HHS U10 HD027049NICHD NIH HHS U10 HD077680The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grants for PPCOSII U10 HD27049, U10 HD38992, U10HD055925, U10 HD39005, U10 HD38998, U10 HD055936, U10 HD055942, U10 HD055944
6 · The paper itself

Abstract

purposeTo compare saline infusion sonohysterography (SIS) versus hysterosalpingogram (HSG) for confirmation of tubal patency.

methodsSecondary analysis of a randomized controlled trial, Pregnancy in Polycystic Ovary Syndrome II (PPCOS II). Seven hundred fifty infertile women (18-40 years old) with polycystic ovary syndrome (PCOS) were randomized to up to 5 cycles of letrozole or clomiphene citrate. Prior to enrollment, tubal patency was determined by HSG, the presence of free fluid in the pelvis on SIS, laparoscopy, or recent intrauterine pregnancy. Logistic regression was conducted in patients who ovulated with clinical pregnancy as the outcome and HSG or SIS as the key independent variable.

resultsAmong women who ovulated, 414 (66.9%) had tubal patency confirmed by SIS and 187 (30.2%) had at least one tube patent on HSG. Multivariable analysis indicated that choice of HSG versus SIS did not have a significant relationship on likelihood of clinical pregnancy, after adjustment for treatment arm, BMI, duration of infertility, smoking, and education (OR 1.14, 95% CI 0.77, 1.67, P = 0.52). Ectopic pregnancy occurred more often in women who had tubal patency confirmed by HSG compared to SIS (2.8% versus 0.6%, P = 0.02).

conclusionsIn this large cohort of women with PCOS, there was no significant difference in clinical pregnancy rate between women who had tubal patency confirmed by HSG versus SIS. SIS is an acceptable imaging modality for assessment of tubal patency in this population.

Indexed as

AdolescentAdultFallopian TubesFemaleHumansHysterosalpingographyInfertility, FemaleLaparoscopyOvulationPolycystic Ovary SyndromePregnancyPregnancy RateUltrasonographyYoung AdultHysterosalpingographyPolycystic ovary syndromeSaline infusion sonohysterographySaline ultrasound

Identifiers

PMID30194618
PMCPMC6289919
OpenAlexW2892192177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.