Evidence map›Paper›PMID 30194587›Full record

ArticleJournal of neurovirology2018

Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics.

Sergio M de Almeida, Michelli F Oliveira, Antoine Chaillon, Indianara Rotta, Clea E Ribeiro, Ana Paula de Pereira, Davey Smith, Scott Letendre, Ronald J Ellis

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sergio M de AlmeidaUniversidade Federal do Paraná, Curitiba, Paraná, Brazil. sergio.ma@ufpr.br.
Michelli F OliveiraUniversity of California, San Diego, San Diego, CA, USA.
Antoine ChaillonUniversity of California, San Diego, San Diego, CA, USA.
Indianara RottaUniversidade Federal do Paraná, Curitiba, Paraná, Brazil.
Clea E RibeiroUniversidade Federal do Paraná, Curitiba, Paraná, Brazil.
Ana Paula de PereiraUniversidade Federal do Paraná, Curitiba, Paraná, Brazil.
Davey SmithUniversity of California, San Diego, San Diego, CA, USA.
Scott LetendreUniversity of California, San Diego, San Diego, CA, USA.
Ronald J EllisUniversity of California, San Diego, San Diego, CA, USA.
University of California, San Diego · USUniversidade Federal do Paraná · BRInstituto de Tecnologia do Paraná · BR

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
A Multi-Site Investigation into the Effect of HIV Clade on Neurocognitive ImpairmR01MH083552 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2008 to 2012
$3.3M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
The Prostate as a Reservoir for Residual ReplicationR21AI131971 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAILLON, ANTOINE · 2018 to 2019
$432k
HIV Clade on Cognitive and Neurological Disorders BrazilR21MH076651 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLIS, RONALD J. · 2006 to 2007
$317k
Milliplex FlexMAP 3DS10RR031646 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2011 to 2011
$153k
NCRR NIH HHS S10 RR031646NIAID NIH HHS P30 AI036214NIAID NIH HHS R21 AI131971NIMH NIH HHS K24 MH097673NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH083552NIMH NIH HHS R21 MH076651NIMH NIH HHS R21 MH76651
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) genetic compartmentalization is defined as genetic differences in HIV in different tissue compartments or subcompartments that characterize viral quasispecies. This descriptive, longitudinal study assessed the dynamics of inflammation, humoral immune response, blood-brain barrier, blood-cerebrospinal fluid (CSF) barrier, as well as neuronal injury biomarkers in serially obtained CSF and serum samples from an antiretroviral (ARV) therapy-naïve patient with HIV-1 subtype C with CSF HIV genetic compartmentalization that resolved spontaneously without ARV treatment. The first CSF sample showed an increase in white blood cell (WBC) count (382 cells/mm

Indexed as

AIDS Dementia ComplexBiomarkersHIV-1HumansLongitudinal StudiesMaleMeningitisMiddle AgedBiomarkersBiomarkersCentral nervous systemCompartmentalizationCSFHIVNew generation sequenceSubtype C

Identifiers

PMID30194587
PMCPMC6279585
OpenAlexW2891803547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.