Evidence map›Paper›PMID 30194442›Full record

ArticleScientific reports2018

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Silmara R Sousa, Jeffrey R McArthur, Andreas Brust, Rebecca F Bhola, K Johan Rosengren, Lotten Ragnarsson, Sebastien Dutertre, Paul F Alewood, Macdonald J Christie, David J Adams and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Comparative Venomics ofMarine drugs · 2022
    Article
  13. Article
  14. Article
  15. Prospecting for candidate molecules fromThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  16. A novelActa pharmaceutica Sinica. B · 2021
    Article
  17. Structure of human CaNature · 2021
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silmara R SousaIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Jeffrey R McArthurIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.
Andreas BrustIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Rebecca F BholaDiscipline of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia.
K Johan RosengrenSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia.
Lotten RagnarssonIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.ORCID 0000-0002-7137-1656
Sebastien DutertreInstitut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier - CNRS, Place Eugène Bataillon, 34095, Montpellier Cedex 5, France.
Paul F AlewoodIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Macdonald J ChristieDiscipline of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-0622-609X
David J AdamsIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.ORCID 0000-0002-7030-2288
Irina VetterIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Richard J LewisIMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. r.lewis@imb.uq.edu.au.

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APPDepartment of Health | National Health and Medical Research Council (NHMRC) APP1072113Department of Health | National Health and Medical Research Council (NHMRC) APP1119056
6 · The paper itself

Abstract

Cone snails are a diverse group of predatory marine invertebrates that deploy remarkably complex venoms to rapidly paralyse worm, mollusc or fish prey. ω-Conotoxins are neurotoxic peptides from cone snail venoms that inhibit Ca

Indexed as

Evolution, MolecularAnalgesicsAnimalsCalcium Channel BlockersCalcium Channels, N-TypeCell Line, TumorCells, CulturedGanglia, SpinalHumansNeuralgiaNeurons, Afferentomega-ConotoxinsRatsRats, WistarSnailsAnalgesicsCalcium Channel BlockersCalcium Channels, N-Typeomega-Conotoxins

Identifiers

PMID30194442
PMCPMC6128854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.