ArticleScientific reports2018
Cascade biotransformation of dehydroepiandrosterone (DHEA) by Beauveria species.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products.International journal of molecular sciences · 2025Article
- Antimicrobial activity of new glycoside derivatives of chloroflavones obtained by fungal biotransformation.Scientific reports · 2025Article
- Antimicrobial Activity of Chalcones with a Chlorine Atom and Their Glycosides.International journal of molecular sciences · 2024Article
- Synthesis, fungal biotransformation, and evaluation of the antimicrobial potential of chalcones with a chlorine atom.Scientific reports · 2024Article
- Antimicrobial Properties of Flavonoid Derivatives with Bromine, Chlorine, and Nitro Group Obtained by Chemical Synthesis and Biotransformation Studies.International journal of molecular sciences · 2024Article
- Multienzymatic biotransformation of flavokawain B by entomopathogenic filamentous fungi: structural modifications and pharmacological predictions.Microbial cell factories · 2024Article
- Biotransformation of ΔInternational journal of molecular sciences · 2023Article
- Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products' Bioactivity.International journal of molecular sciences · 2023Article
- Biotransformation of Flavonoids with -NOInternational journal of molecular sciences · 2023Article
- Selective Microbial Conversion of DHEA into 7α-OH-DHEA.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic StrainInternational journal of molecular sciences · 2022Article
- Biosafety evaluation of twoSaudi journal of biological sciences · 2022Article
- Hydroxylation of pregnenolone and dehydroepiandrosterone by zygomycete Backusella lamprospora VKM F-944: selective production of 7α-OH-DHEA.Applied microbiology and biotechnology · 2022Article
- New Glycosylated Dihydrochalcones Obtained by Biotransformation of 2'-Hydroxy-2-methylchalcone in Cultures of Entomopathogenic Filamentous Fungi.International journal of molecular sciences · 2021Article
- Fungal Biotransformation of 2'-Methylflavanone and 2'-Methylflavone as a Method to Obtain Glycosylated Derivatives.International journal of molecular sciences · 2021Article
- The catalytic activity of mycelial fungi towards 7-oxo-DHEA - an endogenous derivative of steroidal hormone dehydroepiandrosterone.Microbial biotechnology · 2021Article
- Dishwashers as an Extreme Environment of Potentially Pathogenic Yeast Species.Pathogens (Basel, Switzerland) · 2021Article
- Divergence of Beauvericin Synthase Gene amongJournal of fungi (Basel, Switzerland) · 2020Article
- Microbial Modifications of Androstane and Androstene Steroids byMolecules (Basel, Switzerland) · 2020Article
- Biotransformation of Methoxyflavones by Selected Entomopathogenic Filamentous Fungi.International journal of molecular sciences · 2020Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beauveria bassiana is an entomopathogenic fungus used as a biological control agent. It is a well-known biocatalyst for the transformation of steroid compounds. Hydroxylations at the 7α or 11α position and oxidation to D-homo lactones are described in the literature. In our study, we examined the diversity of metabolism of five different B. bassiana strains and compared them to already known pathways. According to the literature, 7α and 11α-hydroxy derivatives as well as 3β,11α-dihydroxy-17a-oxa-D-homo-androst-5-en-17-one have been observed. Here we describe new DHEA metabolic pathways and two products not described before: 3β-hydroxy-17a-oxa-D-homo-androst-5-en-7,17-dione and 3β,11α-dihydroxyandrost-5-en-7,17-dione. We also used for the first time another species from this genus, Beauveria caledonica, for steroid transformation. DHEA was hydroxylated at the 7α, 7β and 11α positions and then reactions of oxidation and reduction leading to 3β,11α-dihydroxyandrost-5-en-7,17-dione were observed. All tested strains from the Beauveria genus effectively transformed the steroid substrate using several different enzymes, resulting in cascade transformation.
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