ArticleNature communications2018
Antagonistic chemical coupling in self-reconfigurable host-guest protocells.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 104 citations in OpenAlex.
- Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks.Nature chemistry · 2026Article
- Nanomaterial Integration at Liquid-Liquid Interfaces for Green Catalysis.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Reconfiguration of Multiphase Coacervate Droplets Into Self-Regulated Nested Artificial Cells.Angewandte Chemie (International ed. in English) · 2026Article
- Complex Coacervate Emulsions as a Strategy to Stabilize Enzymes for Catalysis in Organic Solvents.ACS macro letters · 2026Article
- Self-Coacervation of Oligo(ethylene glycol) and Oligo(2-ethyl-2-oxazoline)-Based Double Hydrophilic Brush Block Copolymers in Aqueous Solution.Macromolecular rapid communications · 2025Article
- Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Stabilizing Water-in-Water Emulsions Using Oil Droplets.Molecules (Basel, Switzerland) · 2025Article
- Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.Angewandte Chemie (International ed. in English) · 2025Article
- Liquid-liquid phase separation-boosted transmembrane delivery in interactive protocell communities.Nature communications · 2025Article
- Biomimetic Materials to Fabricate Artificial Cells.Chemical reviews · 2024Review
- Coacervate Droplets as Biomimetic Models for Designing Cell-Like Microreactors.Macromolecular rapid communications · 2024Review
- Supramolecular fibrillation in coacervates and other confined systems towards biomimetic function.Communications chemistry · 2024Review
- Self-assembly of stabilized droplets from liquid-liquid phase separation for higher-order structures and functions.Communications chemistry · 2024Review
- Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Autonomic Integration in Nested Protocell Communities.Journal of the American Chemical Society · 2023Article
- Facile and Scalable Synthesis of Metal- and Nitrogen-Doped Carbon Nanotubes for Efficient Electrochemical COACS sustainable chemistry & engineering · 2023Article
- Membranized Coacervate Microdroplets: from Versatile Protocell Models to Cytomimetic Materials.Accounts of chemical research · 2023Review
- Cascade reaction networks within audible sound induced transient domains in a solution.Nature communications · 2022Article
- Synthetic Cells: From Simple Bio-Inspired Modules to Sophisticated Integrated Systems.Angewandte Chemie (International ed. in English) · 2022Review
- Triggerable Protocell Capture in Nanoparticle-Caged Coacervate Microdroplets.Journal of the American Chemical Society · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Fabrication of compartmentalised chemical systems with nested architectures and biomimetic properties has important implications for controlling the positional assembly of functional components, spatiotemporal regulation of enzyme cascades and modelling of proto-organelle behaviour in synthetic protocells. Here, we describe the spontaneous capture of glucose oxidase-containing proteinosomes in pH-sensitive fatty acid micelle coacervate droplets as a facile route to multi-compartmentalised host-guest protocells capable of antagonistic chemical and structural coupling. The nested system functions co-operatively at low-substrate turnover, while high levels of glucose give rise to pH-induced disassembly of the droplets, release of the incarcerated proteinosomes and self-reconfiguration into spatially organised enzymatically active vesicle-in-proteinosome protocells. Co-encapsulation of antagonistic enzymes within the proteinosomes produces a sequence of self-induced capture and host-guest reconfiguration. Taken together, our results highlight opportunities for the fabrication of self-reconfigurable host-guest protocells and provide a step towards the development of protocell populations exhibiting both synergistic and antagonistic modes of interaction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.