Evidence map›Paper›PMID 30194336›Full record

Trial reportScientific reports2018

Early postoperative controlling nutritional status (CONUT) score is associated with complication III-V after hepatectomy in hepatocellular carcinoma: A retrospective cohort study of 1,334 patients.

Lei Li, Chang Liu, Jiayin Yang, Hong Wu, Tianfu Wen, Wentao Wang, Bo Li, Lvnan Yan

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei LiDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Chang LiuDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Jiayin YangDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China. yangjygyz@163.com.ORCID 0000-0002-3442-7390
Hong WuDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tianfu WenDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Wentao WangDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Bo LiDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.
Lvnan YanDepartment of Liver Surgery & Liver transplantation center, West China Hospital of Sichuan University, Chengdu, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative complication III-V is closely related with hepatectomy-related mortality for hepatocellular carcinoma (HCC) patients. The aim of the study was to investigate the relationship between CONUTS and postoperative complication III-V. 1334 HCC patients who underwent hepatectomy were divided into two groups: high CONUTS group (early postoperative CONUTS ≥ 8, n = 659) and low CONUTS group (early postoperative CONUTS < 8, n = 675). The characteristics and clinical outcomes were compared and analyzed. Risk factors for postoperative complication III-V were evaluated by univariate and multivariate analysis. early postoperative CONUTS showed a good prediction ability for postoperative complication III-V (AUROC = 0.653, P < 0.001), with the cut-off value of 8. The high CONUTS group had higher incidence of postoperative pulmonary complications (12.0% vs 7.9%, P = 0.011), bile leakage (2.6% vs 0.9%, P = 0.018), intra-abdominal hemorrhage (4.9% vs 1.6%, P = 0.001), postoperative liver failure Grade C (3.6% vs 1.0%, P = 0.002), complication III-V (15.6% vs 6.2%, P < 0.001), length of ICU stay > 48 hours (9.4% vs 4.1%, P < 0.001) and mortality in 90 days (2.6% vs 0.4%, P = 0.001), longer period of postoperative hospitalization (10 (8-13) vs 9 (7-11) days, P < 0.001). Multivariable analysis revealed that early postoperative CONUTS ≥ 8 (OR = 2.054, 95%CI = 1.371-3.078, P < 0.001) was independently associated with postoperative complication III-V. Early postoperative CONUTS ≥ 8 was identified as a novel risk factor for postoperative complication III-V, and should be further evaluated as a predictive marker for who are to undergo liver resection.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLung DiseasesNutritional StatusPostoperative HemorrhageAdultFemaleHepatectomyHumansIntensive Care UnitsLiver FailureMaleMiddle AgedMortalityRetrospective StudiesRisk Factors

Identifiers

PMID30194336
PMCPMC6128835

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.