ArticleScientific reports2018
Analysis By Deep Sequencing of Discontinued Neurotropic Yellow Fever Vaccine Strains.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Intra-Host Diversity of Dengue Virus in Mosquito Vectors.Frontiers in cellular and infection microbiology · 2022Review
- Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity.NPJ vaccines · 2021Article
- The Present and Future of Yellow Fever Vaccines.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Testing the genomic stability of the Brazilian yellow fever vaccine strain using next-generation sequencing data.Interface focus · 2021Article
- Attenuated dengue viruses are genetically more diverse than their respective wild-type parents.NPJ vaccines · 2021Article
- Genomic diversity contributes to the neuroinvasiveness of the Yellow fever French neurotropic vaccine.NPJ vaccines · 2021Article
- Article
- A clinician's perspective on yellow fever vaccine-associated neurotropic disease.Journal of travel medicine · 2020Review
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- Article
- Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti.PLoS neglected tropical diseases · 2019Article
- Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep.Frontiers in genetics · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Deep sequencing of live-attenuated viral vaccines has focused on vaccines in current use. Here we report characterization of a discontinued live yellow fever (YF) vaccine associated with severe adverse events. The French neurotropic vaccine (FNV) strain of YF virus was derived empirically in 1930 by 260 passages of wild-type French viscerotropic virus (FVV) in mouse brain. The vaccine was administered extensively in French-speaking Africa until discontinuation in 1982, due to high rates of post-vaccination encephalitis in children. Using rare archive strains of FNV, viral RNAs were sequenced and analyzed by massively parallel, in silico methods. Diversity and specific population structures were compared in reference to the wild-type parental strain FVV, and between the vaccine strains themselves. Lower abundance of polymorphism content was observed for FNV strains relative to FVV. Although the vaccines were of lower diversity than FVV, heterogeneity between the vaccines was observed. Reversion to wild-type identity was variably observed in the FNV strains. Specific population structures were recovered from vaccines with neurotropic properties; loss of neurotropism in mice was associated with abundance of wild-type RNA populations. The analysis provides novel sequence evidence that FNV is genetically unstable, and that adaptation of FNV contributed to the neurotropic adverse phenotype.
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