ArticleScientific reports2018
Mammillary body regulates state-dependent fear by alternating cortical oscillations.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Two distinct cell types of the medial mammillary body forming segregated subcircuits.Molecular psychiatry · 2025Article
- State-dependent memory retrieval: insights from neural dynamics and behavioral perspectives.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Acquiring new memories in neocortex of hippocampal-lesioned mice.Nature communications · 2022Article
- DisruptedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Progression in Time of Dentate Gyrus Granule Cell Layer Widening due to Excitotoxicity Occurs along In Vivo LTP Reinstatement and Contextual Fear Memory Recovery.Neural plasticity · 2022Article
- High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABANeurobiology of learning and memory · 2021Article
- State-Dependent Memory: Neurobiological Advances and Prospects for Translation to Dissociative Amnesia.Frontiers in behavioral neuroscience · 2018Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
State-dependent memory describes a phenomenon that memory will be efficiently retrieved only when the brain state during retrieval matches the state during encoding. While a variety of psychoactive drugs, such as ethanol, cocaine, morphine and NMDA receptor antagonists, are able to induce state-dependent memory, the biological hallmark of brain state and neural mechanism of its regulation are still unknown. In this study, we found that MK-801 enhanced delta oscillations in awake mice, representing a drug-induced brain state, in which fear memory could only be successfully retrieved when the same drug condition was presented. We identified a key nucleus, mammillary body (MB), which regulates the specific brain state associated with MK-801. Chemogenetic silencing of MB neurons enhanced cortical delta oscillations and generated state-dependent memory. Moreover, optogenetic reconstitution of delta oscillations alone facilitated retrieval of fear memory encoded under MK-801. Our results indicated that delta oscillations in awake animals defined a specific brain state, in which memory formed is inaccessible under the normal condition, shining light on the neural mechanism underlying the fluctuation of memory retrieval and the role of MB in memory encoding and recall.
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