ArticleScientific reports2018
Robust increase of leaf size by Arabidopsis thaliana GRF3-like transcription factors under different growth conditions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Interplay among ZF-HD and GRF transcription factors during Arabidopsis leaf development.Plant physiology · 2023Pooled it
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- Integrative machine learning and gene regulatory network analysis identifies novel genes for leafy head formation in Brassica rapa and B. oleracea.Molecular horticulture · 2026Article
- Autopolyploidization-Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Loci and natural alleles for leaf length and width revealed by a genome wide association study in adzuki bean.BMC plant biology · 2025Article
- Genome-Wide Identification and Characterization of the Growth-Regulating Factor Gene Family Responsive to Abiotic Stresses and Phytohormone Treatments inInternational journal of molecular sciences · 2025Article
- CLAVATA3 Signaling Buffers Arabidopsis Shoot Apical Meristem Activity in Response to Photoperiod.International journal of molecular sciences · 2024Article
- Article
- Genome-wide identification and expression profiling of growth‑regulating factor (GRF) and GRF‑interacting factor (GIF) gene families in chickpea and pigeonpea.Scientific reports · 2024Article
- Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida).BMC genomics · 2024Article
- Genome-Wide Analysis of Flax (International journal of molecular sciences · 2023Article
- The SOD7/DPA4-GIF1 module coordinates organ growth and iron uptake in Arabidopsis.Nature plants · 2023Article
- Geographic-genomic and geographic-phenotypic differentiation of theHorticulture research · 2023Article
- Enhancing alfalfa resistance to Spodoptera herbivory by sequestering microRNA396 expression.Plant cell reports · 2023Article
- An optimized pipeline for live imaging whole Arabidopsis leaves at cellular resolution.Plant methods · 2023Article
- Molecular Mechanisms of the miR396b-Evolutionary bioinformatics online · 2023Article
- Identification of growth regulators using cross-species network analysis in plants.Plant physiology · 2022Article
- PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome-wide identification of growth-regulating factor transcription factor family related to leaf and stem development in alfalfa.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
An increase in crop yield is essential to reassure food security to meet the accelerating global demand. Several genetic modifications can increase organ size, which in turn might boost crop yield. Still, only in a few cases their performance has been evaluated under stress conditions. MicroRNA miR396 repress the expression of GROWTH-REGULATING FACTOR (GRF) genes that codes for transcription factors that promote organ growth. Here, we show that both Arabidopsis thaliana At-GRF2 and At-GRF3 genes resistant to miR396 activity (rGRF2 and rGRF3) increased organ size, but only rGRF3 can produce this effect without causing morphological defects. Furthermore, introduction of At-rGRF3 in Brassica oleracea can increase organ size, and when At-rGRF3 homologs from soybean and rice are introduced in Arabidopsis, leaf size is also increased. This suggests that regulation of GRF3 activity by miR396 is important for organ growth in a broad range of species. Plants harboring rGRF3 have larger leaves also under drought stress, a condition that stimulates miR396 accumulation. These plants also showed an increase in the resistance to virulent bacteria, suggesting that the size increment promoted by rGRF3 occurs without an obvious cost on plant defenses. Our findings indicate that rGRF3 can increase plant organ size under both normal and stress conditions and is a valuable tool for biotechnological applications.
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