ArticleNature communications2018
A rationally designed JAZ subtype-selective agonist of jasmonate perception.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Multiomics reveals postherbivory tea leaves restructure endophytic microbiota to resist disease and boost saccharide metabolism to promote growth.Horticulture research · 2026Article
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- (3R, 7S)-11-hydroxy-jasmonic acid is a major oxidative shunt product of jasmonic acid catabolism in Arabidopsis thaliana.Nature communications · 2026Article
- A Reactive Antagonist Strategy: Cysteine-Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A synthetic jasmonate receptor agonist uncouples the growth-defense trade-off in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chemical application improves stress resilience in plants.Plant molecular biology · 2025Review
- Genome-wide identification and comprehensive analysis of theFrontiers in plant science · 2025Article
- A frameshift mutation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Amide conjugates of the jasmonate precursor cis-(+)-12-oxo-phytodienoic acid regulate its homeostasis during plant stress responses.Plant physiology · 2024Article
- Multiomic analyses reveal key sectors of jasmonate-mediated defense responses in rice.The Plant cell · 2024Article
- A structure-redesigned intrinsically disordered peptide that selectively inhibits a plant transcription factor in jasmonate signaling.PNAS nexus · 2024Article
- Article
- ΔiScience · 2024Article
- Two distinct modes of action of molecular glues in the plant hormone co-receptor COI1-JAZ system.iScience · 2024Article
- Physiological, Proteomic, and Resin Yield-Related Genes Expression Analysis Provides Insights into the Mechanisms Regulating Resin Yield in Masson Pine.International journal of molecular sciences · 2023Article
- Diversification of JAZ-MYC signaling function in immune metabolism.The New phytologist · 2023Article
- Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine.Communications biology · 2023Article
- Transcriptome analysis ofFrontiers in genetics · 2023Article
- Full-length RNA sequencing reveals the mechanisms by which an TSWV-HCRV complex suppresses plant basal resistance.Frontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The phytohormone 7-iso-(+)-jasmonoyl-L-isoleucine (JA-Ile) mediates plant defense responses against herbivore and pathogen attack, and thus increases plant resistance against foreign invaders. However, JA-Ile also causes growth inhibition; and therefore JA-Ile is not a practical chemical regulator of plant defense responses. Here, we describe the rational design and synthesis of a small molecule agonist that can upregulate defense-related gene expression and promote pathogen resistance at concentrations that do not cause growth inhibition in Arabidopsis. By stabilizing interactions between COI1 and JAZ9 and JAZ10 but no other JAZ isoforms, the agonist leads to formation of JA-Ile co-receptors that selectively activate the JAZ9-EIN3/EIL1-ORA59 signaling pathway. The design of a JA-Ile agonist with high selectivity for specific protein subtypes may help promote the development of chemical regulators that do not cause a tradeoff between growth and defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.