ArticleScience immunology2018
Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13
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In one paragraph
Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Overview of allergic disease: Pathogenesis of allergic inflammation - WAO White Book on Allergy 2026 - 2.1.The World Allergy Organization journal · 2026Review
- The immunology of asthma and chronic rhinosinusitis.Nature reviews. Immunology · 2025Review
- The immunology of asthma.Nature immunology · 2025Review
- Mechanistic modelling of allergen-induced airways disease in early life.Scientific reports · 2025Article
- Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma.The Journal of clinical investigation · 2024Article
- T helper 2 cells in asthma.The Journal of experimental medicine · 2023Review
- Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.American journal of respiratory cell and molecular biology · 2023Article
- The ins and outs of innate and adaptive type 2 immunity.Immunity · 2023Review
- Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma.Allergy, asthma & immunology research · 2023Article
- Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma.Frontiers in immunology · 2022Review
- Airway immune response in the mouse models of obesity-related asthma.Frontiers in physiology · 2022Review
- Emerging Roles of Non-Coding RNAs in Childhood Asthma.Frontiers in pharmacology · 2022Review
- Implications of Gut Microbiota in Complex Human Diseases.International journal of molecular sciences · 2021Review
- Microbiota Signals during the Neonatal Period Forge Life-Long Immune Responses.International journal of molecular sciences · 2021Review
- Analysis of Results of Specific IgE in 100 Atopic Dermatitis Patients with the Use of Multiplex Examination ALEX2-Allergy Explorer.International journal of molecular sciences · 2021Article
- Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure.The Journal of allergy and clinical immunology · 2021Article
- Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum.Frontiers in immunology · 2021Review
- Respiratory Viral and Bacterial Factors That Influence Early Childhood Asthma.Frontiers in allergy · 2021Review
- Fms-Like Tyrosine Kinase 3-Independent Dendritic Cells Are Major Mediators of Th2 Immune Responses in Allergen-Induced Asthmatic Mice.International journal of molecular sciences · 2020Article
- Early origins of lung disease: towards an interdisciplinary approach.European respiratory review : an official journal of the European Respiratory Society · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 4 institutions in 2 countries.
Sejal SaglaniInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK. c.lloyd@imperial.ac.uk s.saglani@imperial.ac.uk.ORCID 0000-0001-5192-6418
Lisa G GregoryInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Avneet K MangheraInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
William J BranchettInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-4353-4857
Faith UwadiaeInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-6660-6051
Lewis J EntwistleInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-6043-6741
R A OliverInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Jessica E VasiliouInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-5288-6478
Rebekah SherburnInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-1683-3977
Stephen LuiInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
F PutturInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
David VöhringerUniversitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg Wasserturmstrasse 3-5, 91054 Erlangen, Germany.ORCID 0000-0001-6650-0639
Simone A WalkerInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
James BuckleyInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-9567-1621
Ruth GrychtolInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Valentina FainardiInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-4601-7484
Laura DenneyInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Adam ByrneInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK.
Erika von MutiusDr Von Hauner Childrens Hospital of Ludwig-Maximilians-Universitaet of Munich and Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.ORCID 0000-0002-8893-4515
Andrew BushRespiratory Paediatrics, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-6756-9822
Clare M LloydInflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK. c.lloyd@imperial.ac.uk s.saglani@imperial.ac.uk.ORCID 0000-0001-8977-6726
Imperial College London · GBRoyal Brompton Hospital · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHelmholtz Zentrum München · DE
Funding
Wellcome Trust 083586Wellcome Trust 083586/Z/07/ZWellcome Trust 087618Wellcome Trust 087618/Z/08/ZWellcome Trust 107059Wellcome Trust 107059/Z/15/Z
Abstract
Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) or
Indexed as
AcinetobacterAllergensAlternariaAnimalsAnimals, NewbornCD4-Positive T-LymphocytesFemaleInterleukin-13Interleukin-33MaleMice, Inbred BALB CMice, KnockoutMice, SCIDPyroglyphidaeRespiratory HypersensitivityAllergensIl33 protein, mouseInterleukin-13Interleukin-33
Identifiers
What OpenQuestion holds
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LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.