Evidence map›Paper›PMID 30193906›Full record

ReviewSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2018

Adipose tissue and the physiologic underpinnings of metabolic disease.

Robert W O'Rourke

Abstract readReview
In one paragraph

Review in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  6. Adrenic acid: A promising biomarker and therapeutic target (Review).International journal of molecular medicine · 2025
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  12. Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Robert W O'RourkeDepartment of Surgery, University of Michigan Medical School, Michigan Medicine, and Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan. Electronic address: rorourke@med.umich.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Adipose Tissue Macrophage Control of Metabolic Dysfunction in DiabetesR01DK115190 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, CAREY N, O'ROURKE, ROBERT W · 2017 to 2020
$2.3M
Targeting hypoxia-inducible mediators to manipulate human adipocyte phenotypeR01DK097449 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'ROURKE, ROBERT W · 2013 to 2017
$1.7M
Personalized Gait Training with Feedback to Reduce Knee Pain from OsteoarthritisI01RX001811 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI KOLESAR, JULIE ANN · 2016 to 2021
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CSRD VA I01 CX001811NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK097449NIDDK NIH HHS R01 DK115190
6 · The paper itself

Abstract

Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics used to quantify adiposity and its association with metabolic disease, including body mass index, have limitations with important clinical implications. An understanding of the molecular and cellular mechanisms by which adipose tissue regulates systemic metabolism and contributes to metabolic disease will lead to next-generation adipose tissue-based therapy.

Indexed as

Adipose TissueMetabolic DiseasesBody Mass IndexCell- and Tissue-Based TherapyHumansObesityAdipose tissueBody mass indexCell stress responsesMetabolic diseaseObesity

Identifiers

PMID30193906
PMCPMC6289667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.