Trial reportThe Journal of allergy and clinical immunology2019
The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).
2 registry-linked trialsAbstract readClinical TrialLetterMulticenter Study
In one paragraph
Trial report in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children With SCID Disorders (RDCRN PIDTC-6901)
A Retrospective and Cross-Sectional Analysis of Patients Treated for SCID Since January 1,1968 (RDCRN PIDTC-6902)
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Newborn screening for severe combined immunodeficiency in the NHS newborn blood spot screening programme: a systematic review.Health technology assessment (Winchester, England) · 2026Pooled it
- Lentiviral Gene Therapy for Artemis-Deficient SCID.The New England journal of medicine · 2022Trial
- Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC.Blood · 2022Trial
- Nodular lymphoid hyperplasia in atypical SCID due to IL7R mutations mimicking CVID.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Novel molecular assays for monitoring T cell function after HSCT in two siblings with variants inJournal of human immunity · 2026Article
- International clinical consensus on leukocyte adhesion deficiency-I: Modified Delphi analysis.The journal of allergy and clinical immunology. Global · 2026Article
- The ClinGen Severe Combined Immunodeficiency Disease Variant Curation Expert Panel: Specifications for classification of variants in ADA, DCLRE1C, IL2RG, IL7R, JAK3, RAG1, and RAG2.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Mastering genetics for your clinic: A step-by-step guide.The Journal of allergy and clinical immunology · 2025Review
- The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia.Frontiers in immunology · 2025Review
- Genetically corrected RAG2-SCID human hematopoietic stem cells restore V(D)J-recombinase and rescue lymphoid deficiency.Blood advances · 2024Article
- Mending RAG2: gene editing for treatment of RAG2 deficiency.Blood advances · 2024Article
- Parental Engagement in Identifying Information Needs After Newborn Screening for Families of Infants with Suspected Athymia.Journal of clinical immunology · 2024Article
- Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.Science translational medicine · 2024Article
- Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark study.The Journal of allergy and clinical immunology · 2024Article
- Impact of newborn screening for SCID on the management of congenital athymia.The Journal of allergy and clinical immunology · 2024Article
- Clinical, immunological and molecular findings of 8 patients with typical and atypical severe combined immunodeficiency: identification of 7 novel mutations by whole exome sequencing.Genes and immunity · 2023Article
- Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.Lancet (London, England) · 2023Article
- [Principles of the diagnostics of inborn errors of immunity].Zeitschrift fur Rheumatologie · 2023Review
- Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders.Journal of clinical immunology · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Christopher C DvorakBenioff Children's Hospital, University of California, San Francisco, Calif. Electronic address: Christopher.dvorak@ucsf.edu.
Elie HaddadCHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Rebecca H BuckleyDuke University, Durham, NC.
Morton J CowanBenioff Children's Hospital, University of California, San Francisco, Calif.
Brent LoganMedical College of Wisconsin, Milwaukee, Wis.
Linda M GriffithNational Institute of Allergy and Infectious Diseases, Bethesda, Md.
Donald B KohnUniversity of California, Los Angeles, Calif.
Sung-Yun PaiBoston Children's Hospital, Boston, Mass.
Luigi NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
William ShearerTexas Children's Hospital, Houston, Tex.
Susan ProckopMemorial Sloan Kettering Cancer Center, New York, NY.
Neena KapoorChildren's Hospital Los Angeles, Los Angeles, Calif.
Jennifer HeimallChildren's Hospital Philadelphia, Philadelphia, Pa.
Sonali ChaudhuryLurie Children's Hospital Chicago, Chicago, Ill.
David ShyrPrimary Children's Hospital, Salt Lake City, Utah.
Sharat ChandraCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Geoff CuvelierCancerCare Manitoba, Winnipeg, Manitoba, Canada.
Theodore MooreUniversity of California, Los Angeles, Calif.
Shalini ShenoySt Louis Children's Hospital, St Louis, Mo.
Fred GoldmanChildren's Hospital Alabama, Birmingham, Ala.
Angela R SmithUniversity of Minnesota Masonic Children's Hospital, Minneapolis, Minn.
Gauri SunkersettJohns Hopkins All Children's Hospital, St Petersburg, Fla.
Mark Vander LugtUniversity of Michigan Health System, Ann Arbor, Mich.
Emi CaywoodAlfred I duPont Hospital for Children, Wilmington, Del.
Troy QuiggMethodist Children's Hospital of South Texas, San Antonio, Tex.
Troy TorgersonSeattle Children's Hospital, Seattle, Wash.
Shanmuganathan ChandrakasanChildren's Healthcare of Atlanta, Atlanta, Ga.
John CraddockChildren's Hospital Colorado, Aurora, Colo.
Blachy J Dávila SaldañaChildren's National Medical Center, Washington, DC.
Alfred GillioHackensack University Medical Center, Hackensack, NJ.
Evan ShereckOregon Health & Science University, Portland, Ore.
Victor AquinoUniversity of Texas Southwestern Medical Center Dallas, Dallas, Tex.
Kenneth DeSantesUniversity of Wisconsin, American Family Children's Hospital, Madison, Wis.
Alan KnutsenCardinal Glennon Children's Hospital, St Louis, Mo.
Monica ThakarChildren's Hospital of Wisconsin, Milwaukee, Wis.
Lolie YuChildren's Hospital Louisiana State University Health Sciences Center, Shreveport, La.
Jennifer M PuckBenioff Children's Hospital, University of California, San Francisco, Calif.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MData Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MPB vs. BMU01HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2001 to 2010
$63.3MRare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1MTraining of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAI, SUNG-YUN · 2009 to 2023
$23.3MData Management and Coordinating Center (DMCC)U54NS064808 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2009 to 2013
$16.5MAtlanta Pediatric Scholars ProgramK12HD072245 · NICHD · EMORY UNIVERSITY · PI Shari Barkin · 2012 to 2026
$5.5MBlood and Marrow Transplant Clinical Trials NetworkU10HL069254 · NHLBI · UNIVERSITY OF UTAH · PI PULSIPHER, MICHAEL A · 2011 to 2016
$839kPrimary Immune Deficiency Treatment Consortium Annual Scientific MeetingR13AI094943 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PUCK, JENNIFER M. · 2011 to 2025
$239kNCATS NIH HHS U01 TR001263NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069294NHLBI NIH HHS U10 HL069254NIAID NIH HHS R13 AI094943NIAID NIH HHS U54 AI082973NICHD NIH HHS K12 HD072245NINDS NIH HHS U54 NS064808
Abstract
PubMed holds no abstract for this paper.
Indexed as
CanadaChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleSevere Combined ImmunodeficiencyUnited States
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT01186913ClinicalTrials.gov
NCT01346150ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.