Evidence map›Paper›PMID 30193783›Full record

ReviewJournal of cardiothoracic and vascular anesthesia2019

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Brandi A Bottiger, Alina Nicoara, Laurie D Snyder, Paul E Wischmeyer, Jacob N Schroder, Chetan B Patel, Mani A Daneshmand, Robert N Sladen, Kamrouz Ghadimi

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cardiothoracic and vascular anesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Frailty in Pulmonary Hypertension: A Multidimensional Comorbidity.Annals of the American Thoracic Society · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Prevalence of Violence against Providers in Heart and Lung Transplant Programs.International journal of environmental research and public health · 2023
    Article
  8. Old Age and Frailty in Deceased Organ Transplantation and Allocation-A Plea for Geriatric Assessment and Prehabilitation.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the scientific registry of transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Article
  14. Review
  15. Pathobiology of frailty in lung disease.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  16. Right Ventricular Aneurysmal Formation: The Right (La)Place at the Right Time.Journal of cardiothoracic and vascular anesthesia · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Brandi A BottigerDivision of Cardiothoracic Anesthesiology, Department of Anesthesiology & Critical Care, Duke University, Durham, NC.
Alina NicoaraDivision of Cardiothoracic Anesthesiology, Department of Anesthesiology & Critical Care, Duke University, Durham, NC.
Laurie D SnyderDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, NC.
Paul E WischmeyerDivision of Critical Care Medicine, Department of Anesthesiology & Critical Care, Duke University, Durham, NC; Duke Clinical Research Institute, Durham, NC.
Jacob N SchroderDivision of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, NC.
Chetan B PatelDivision of Cardiology, Department of Medicine, Duke University, Durham, NC.
Mani A DaneshmandDivision of Cardiothoracic Surgery, Department of Surgery, Duke University, Durham, NC.
Robert N SladenDepartment of Anesthesiology, Columbia University, New York, NY.
Kamrouz GhadimiDivision of Cardiothoracic Anesthesiology, Department of Anesthesiology & Critical Care, Duke University, Durham, NC; Division of Critical Care Medicine, Department of Anesthesiology & Critical Care, Duke University, Durham, NC. Electronic address: kamrouz.ghadimi@duke.edu.
Duke University · USClinical Research Institute · USColumbia University · US

Funding

INTEGRATED TRAINING IN ANESTHESIOLOGY RESEARCHT32GM008600 · NIGMS · DUKE UNIVERSITY · PI Miriam Treggiari · 1996 to 2026
$6.6M
NIGMS NIH HHS T32 GM008600
6 · The paper itself

Abstract

The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary failure may be under consideration for heart or lung transplantation along with bridging therapies such as ventricular assist device implantation or venovenous extracorporeal membrane oxygenation, respectively. Early identification of frail patients in an attempt to modify the risk of postoperative morbidity and mortality has become an important area of study over the last decade. Many quantification tools and risk prediction models for frailty have been developed but have not been evaluated extensively or standardized in the cardiothoracic transplant candidate population. Heightened awareness of frailty, coupled with a better understanding of distinct cellular mechanisms and biomarkers apart from end-stage organ disease, may play an important role in potentially reversing frailty related to organ failure. Furthermore, the clinical management of these critically ill patients may be enhanced by waitlist and postoperative physical rehabilitation and nutritional optimization.

Indexed as

Age FactorsFrailtyHeart FailureHeart TransplantationHumansLung DiseasesLung TransplantationPerioperative CarePostoperative Complicationsbiomarkercachexiacardiothoracic surgerychronic lung diseaseCOPDcritical careECMOfrailtygrowth hormoneheart failureheart transplantationIABPICUIGF-1lung transplantationLVADmetabolismnutritionrehabilitationsarcopenia

Identifiers

PMID30193783
PMCPMC6368901
OpenAlexW2886638453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.