ArticleBritish journal of cancer1986
Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma.
Article in British journal of cancer, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 119 citations in OpenAlex.
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- Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer.Journal of immunology research · 2021Review
- Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity.BioMed research international · 2016Review
- A study on assessment of mast cells in oral squamous cell carcinoma.Annals of medical and health sciences research · 2014Article
- The impact of the immune system on tumor: angiogenesis and vascular remodeling.Frontiers in oncology · 2014Review
- Mast cells as a potential prognostic marker in prostate cancer.Disease markers · 2013Review
- Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Mast cells and histamine: do they influence placental vascular network and development in preeclampsia?Mediators of inflammation · 2012Article
- Review
- Mast cells and T-lymphocytes in juvenile angiofibromas.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2007Article
- Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling.The Journal of nutrition · 2007Article
- Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats.Environmental health perspectives · 2007Article
- Canine transmissible venereal tumour: assessment of mast cell numbers as indicators of the growth phase.Veterinary research communications · 2006Article
- Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid.The Journal of clinical investigation · 2001Article
- Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.Genes & development · 1999Article
- Topical tretinoin increases dermal mast cells, induces epidermal mast cell growth factor (c-kit ligand) and modulates its distribution in hairless mice.Archives of dermatological research · 1996Article
- Mast cells in melanocytic tumours.Archives of dermatological research · 1995Article
- Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II.The Biochemical journal · 1995Article
- Effects of mast cell-macrophage interactions on the production of collagenolytic enzymes by metastatic tumor cells and tumor-derived and stromal fibroblasts.Clinical & experimental metastasis · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Significant numbers of mast cells have been demonstrated histologically around the periphery of the invasive rat mammary adenocarcinoma 13672NF. The number of mast cells at microfoci along the tumour:host tissue junction was significantly greater than that found in normal mammary tissues, and few mast cells were detected within the tumour itself. Mast cell degranulation, often associated with disruption and lysis of the connective tissue matrix, was a common feature in later stages of tumour proliferation. When soluble products derived from purified rat peritoneal mast cells were added to monolayer cultures of rat stromal fibroblasts or tumour cells they stimulated a significant increase in total collagenase production, and the mast cell products were also capable of activating the latent collagenases thus produced. Histological examination indicated that degradation of local collagenous matrix was a common feature of mast cell degranulation, an observation possibly explained by the release of mast cell enzymes and/or the potential of this cell to modulate the expression of collagenolytic activity by surrounding cells. These observations suggest that, at least in some tumours, mast cells contribute to the connective tissue breakdown commonly associated with tumour invasiveness and metastatic spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.