ArticleBMC genomics2018
Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618626 (Cardiovascular Diseases), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Integrated Genomic and Transcriptomic Study RevealsCirculation. Genomic and precision medicine · 2026Article
- Dietary intake, fatty acid in adipose tissue and cardio-metabolic health: cross-sectional study from the TwinsUK cohort.Nutrition & diabetes · 2026Article
- Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?Current obesity reports · 2025Review
- Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD.JHEP reports : innovation in hepatology · 2024Article
- Methylation risk scores are associated with a collection of phenotypes within electronic health record systems.NPJ genomic medicine · 2022Article
- Clinical implications of intermittent Ramadan fasting on stable plaque psoriasis: a prospective observational study.Postepy dermatologii i alergologii · 2022Article
- Influence of Long-Term Fasting on Blood Redox Status in Humans.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntermittent fasting and time-restricted diets are associated with lower risk biomarkers for cardio-metabolic disease. The shared mechanisms underpinning the similar physiological response to these events is not established, but circadian rhythm could be involved. Here we investigated the transcriptional response to fasting in a large cross-sectional study of adipose and skin tissue from healthy volunteers (N = 625) controlling for confounders of circadian rhythm: time of day and season.
resultsWe identified 367 genes in adipose and 79 in skin whose expression levels were associated (FDR < 5%) with hours of fasting conditionally independent of time of day and season, with 19 genes common to both tissues. Among these genes, we replicated 38 in human, 157 in non-human studies, and 178 are novel associations. Fasting-responsive genes were enriched for regulation of and response to circadian rhythm. We identified 99 genes in adipose and 54 genes in skin whose expression was associated to time of day; these genes were also enriched for circadian rhythm processes. In genes associated to both exposures the effect of time of day was stronger and in an opposite direction to that of hours fasted. We also investigated the relationship between fasting and genetic regulation of gene expression, including GxE eQTL analysis to identify personal responses to fasting.
conclusionThis study robustly implicates circadian rhythm genes in the response to hours fasting independently of time of day, seasonality, age and BMI. We identified tissue-shared and tissue-specific differences in the transcriptional response to fasting in a large sample of healthy volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.