ArticleEnvironmental health and preventive medicine2018
Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health.
Article in Environmental health and preventive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Phthalates exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological literature.Environmental science and pollution research international · 2020Pooled it
- Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence.Environment international · 2020Pooled it
- Public health risks related to food safety issues in the food market: a systematic literature review.Environmental health and preventive medicine · 2019Pooled it
- Prenatal and childhood exposure to common plasticizers in relation to emotional and behavioral development through adolescence.The Science of the total environment · 2026Article
- Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort.Environment international · 2025Article
- Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.Journal of xenobiotics · 2025Review
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Identifying critical windows of prenatal phenol, paraben, and pesticide exposure and child neurodevelopment: Findings from a prospective cohort study.The Science of the total environment · 2024Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Prenatal urinary concentrations of phthalate metabolites and behavioral problems in Mexican children: The Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) study.Environmental research · 2021Article
- Autistic-like traits in laboratory rodents exposed to phthalic acid esters during early development - an animal model of autism?Physiological research · 2021Review
- Hokkaido birth cohort study on environment and children's health: cohort profile 2021.Environmental health and preventive medicine · 2021Article
- Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age - An exposome-based approach in 5 European cohorts.The Science of the total environment · 2021Article
- A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment.International journal of environmental research and public health · 2021Review
- Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies.International journal of environmental research and public health · 2021Article
- Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years.Environment international · 2020Article
- Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver.Toxicology and applied pharmacology · 2020Article
- Oxidative stress in liver cell culture from mullet, Liza klunzingeri, induced by short-term exposure to benzo[a]pyrene and nonylphenol.Fish physiology and biochemistry · 2020Article
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
- Endocrine-disrupting chemicals: implications for human health.The lancet. Diabetes & endocrinology · 2020Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundStudies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age.
methodsThe Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed.
resultsThe median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, ∑DBP
conclusionsOur analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.
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