Evidence map›Paper›PMID 30193337›Full record

Trial reportJAMA surgery2018

Effect of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial.

Enrico M Minnella, Rashami Awasthi, Sarah-Eve Loiselle, Ramanakumar V Agnihotram, Lorenzo E Ferri, Francesco Carli

9 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 256 papers, 29 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 29 pooled it
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07462663 phase4not yet recruitingstarted 2027, after this paper: background citation

SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate Surgery Versus a Multimodal Metabolic Optimization and Prehabilitation Strategy Before Surgery in Patients With Atypical Endometrial Hyperplasia or Low-Risk Endometrioid Endometrial Cancer and BMI ≥40 kg/m²

Ran2027Enrolled80Registered outcomes34Posted comparisons0ConditionsAtypical Endometrial Hyperplasia, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, BMI>40, Endometrial CancerArmsDietetic-Nutritional intervention, Endometrial Biopsy With or Without Hysteroscopy, GLP-1 receptor agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
PMID 33755728PMID 33667417PMID 36216945PMID 29266019PMID 17096437PMID 23021687PMID 25791635PMID 27654262PMID 27901412PMID 33397713PMID 34238643PMID 35314087other papers from this trial
Open the trial in the graph
NCT01666158 nacompletednot on this map

Prehabilitation to Enhance Postoperative Functional Capacity Following Esophageal Resection

TypeinterventionalSponsorFranco CarliRan2013 to 2017Enrolled68ConditionsEsophageal Cancer, SurgeryArmsExercise
NCT03798951 naterminatednot on this mapstarted 2019, after this paper: background citation

Evaluation of a Multimodal Program of Prehabilitation in Patients Undergoing Esophagectomy Within an ERAS Pathway

TypeinterventionalSponsorUniversità Vita-Salute San RaffaeleRan2019 to 2024Enrolled21ConditionsEsophageal Cancer SurgeryArmsPrehabilitation
NCT04498208 nacompletednot on this mapstarted 2020, after this paper: background citation

Immune System Modulation by Enhanced vs Standard Prehabilitation Program in Patients Undergoing Elective Major Surgery - a Prospective Monocentric Randomized Single-blinded Controlled Trial

TypeinterventionalSponsorStanford UniversityRan2020 to 2024Enrolled55ConditionsSurgery, Immune System and Related Disorders, Preoperative Care, Gastrointestinal DiseaseArmsPhysical Prehabilitation, Stress Reduction Prehabilitation, Cognitive Prehabilitation, Nutrition Prehabilitation
NCT04617678 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

A Comprehensive Approach to Head and Neck Cancer Prehabilitation

TypeinterventionalSponsorSanford HealthRan2021 to 2026Enrolled80ConditionsCancer of Head and NeckArmsPrehabilitation Program
NCT04715581 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effect of Multicomponent Prehabilitation on Early and Long-term Outcomes in Elderly Patients With Frailty After Digestive Surgery for Cancer: A Randomized-controlled Study

TypeinterventionalSponsorPeking University First HospitalRan2021 to 2028Enrolled540ConditionsOld Age, Debility, Digestive Cancer, SurgeryArmsPreoperative nutritional optimization, Preoperative exercise training, Postoperative exercise training
NCT04789694 phase3recruitingnot on this mapstarted 2021, after this paper: background citation

Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management: A Prospective Randomised Trial.

TypeinterventionalSponsorCharles University, Czech RepublicRan2021 to 2026Enrolled64ConditionsOvarian Cancer, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Endometrial CancerArmsPhysiological intervention, Psychological intervention, Nutritional intervention
NCT07658313 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

From Prehabilitation to Rehabilitation: A Feasibility Trial for Digitally Supported Prehabilitation in Major Visceral Oncologic Surgery

TypeinterventionalSponsorLudwig Boltzmann Institute for Digital Health and PreventionRan2026 to 2027Enrolled30ConditionsGastrointestinal Neoplasms, Pancreatic Neoplasms, Liver Neoplasm, Oesophageal CancerArmsDigitally Supported Multimodal Prehabilitation
NCT07713888 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Multimodal Prehabilitation on Post-operative Recovery in Patients Undergoing Surgery for Upper Gastrointestinal Tract Cancer in Taiwan

TypeinterventionalSponsorTaichung Tzu Chi HospitalRan2026 to 2027Enrolled40ConditionsSurgery of Upper Gastrointestinal Tract CancerArmsPrehabilitation
3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 29 syntheses or guidelines pooled it, 488 citations in OpenAlex.

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  19. Effects of unimodal or multimodal prehabilitation on patients undergoing surgery for esophagogastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Enrico M MinnellaDepartment of Anesthesia, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
Rashami AwasthiDepartment of Anesthesia, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
Sarah-Eve LoiselleDepartment of Anesthesia, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
Ramanakumar V AgnihotramResearch Institute, McGill University Health Centre, Glen Site, Montreal, Quebec, Canada.
Lorenzo E FerriDivision of Thoracic Surgery, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
Francesco CarliDepartment of Anesthesia, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
McGill University Health Centre · CAMontreal General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Preserving functional capacity is a key element in the care continuum for patients with esophagogastric cancer. Prehabilitation, a preoperative conditioning intervention aiming to optimize physical status, has not been tested in upper gastrointestinal surgery to date. Objective: To investigate whether prehabilitation is effective in improving functional status in patients undergoing esophagogastric cancer resection. Design, Setting, and Participants: A randomized clinical trial (available-case analysis based on completed assessments) was conducted at McGill University Health Centre (Montreal, Quebec, Canada) comparing prehabilitation with a control group. Intervention consisted of preoperative exercise and nutrition optimization. Participants were adults awaiting elective esophagogastric resection for cancer. The study dates were February 13, 2013, to February 10, 2017. Main Outcomes and Measures: The primary outcome was change in functional capacity, measured with absolute change in 6-minute walk distance (6MWD). Preoperative (end of the prehabilitation period) and postoperative (from 4 to 8 weeks after surgery) data were compared between groups. Results: Sixty-eight patients were randomized, and 51 were included in the primary analysis. The control group were a mean (SD) age, 68.0 (11.6) years and 20 (80%) men. Patients in the prehabilitation group were a mean (SD) age, 67.3 (7.4) years and 18 (69%) men. Compared with the control group, the prehabilitation group had improved functional capacity both before surgery (mean [SD] 6MWD change, 36.9 [51.4] vs -22.8 [52.5] m; P < .001) and after surgery (mean [SD] 6MWD change, 15.4 [65.6] vs -81.8 [87.0] m; P < .001). Conclusions and Relevance: Prehabilitation improves perioperative functional capacity in esophagogastric surgery. Keeping patients from physical and nutritional status decline could have a significant effect on the cancer care continuum. Trial Registration: ClinicalTrials.gov Identifier: NCT01666158.

Indexed as

AgedEsophageal NeoplasmsExerciseFemaleHumansMaleMiddle AgedNutritional StatusPreoperative CareStomach NeoplasmsWalking

Identifiers

PMID30193337
PMCPMC6583009
OpenAlexW2889934963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.