ArticleCell2018
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers.
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187citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
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187 citing papers in PubMed, 332 citations in OpenAlex.
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- The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes.Diabetologia · 2026Review
- The circadian architecture of tumor immunity: mechanistic insights and treatment strategies.Biomarker research · 2026Review
- Chrono-Exercise Medicine: Why Biological Timing Matters for Human Health.Biomedicines · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- AMPK inhibition and elevated angiogenin are associated with tRNA fragmentation in the male germline exposed to a high-fat diet.Molecular metabolism · 2026Article
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- Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases.Endocrine journal · 2026Review
- Diurnal Regulation and Gene-Specific Vulnerability of Oxidative Alcohol-Metabolizing Enzymes to Circadian Disruption.International journal of molecular sciences · 2026Article
- ZFP42 maintains stemness and rhythmic transcription in human epidermal stem and progenitor cells via CRY1.Communications biology · 2026Article
- Modeling the dynamics of hepatic metabolism: the predominance of 12-hour rhythmicity in metabolic adaptation.Cellular and molecular life sciences : CMLS · 2026Article
- Lipid dysregulation as a convergent pathway linking environmental exposures to stroke.Frontiers in aging neuroscience · 2026Review
- Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study.Frontiers in molecular biosciences · 2026Article
- Restoring circadian disrupted gut microbial metabolite rhythms with phytochemicals: a new avenue against metabolic disease.Frontiers in microbiology · 2026Review
- Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer.Nature metabolism · 2026Article
- The Leucine-mTOR-Autophagy Axis in Granulosa Cells Mediates Circadian Disruption-Induced Anovulation.International journal of biological sciences · 2026Article
127 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 6 institutions in 5 countries.
Kenneth A DyarInstitute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Dominik LutterInstitute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Anna ArtatiInstitute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg Germany.
Nicholas J CegliaInstitute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Yu LiuInstitute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Danny ArmentaInstitute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Martin JastrochInstitute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Sandra SchneiderDepartment of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK.
Sara de MateoCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Marlene CervantesCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Serena AbbondanteCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Paola TogniniCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Ricardo Orozco-SolisCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Kenichiro KinouchiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Christina WangHarbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA.
Ronald SwerdloffHarbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA.
Seba NadeefBESE Division, KAUST Environmental Epigenetics Program, King Abdullah University Science and Technology, Thuwal, Saudi Arabia.
Selma MasriCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Pierre MagistrettiBESE Division, KAUST Environmental Epigenetics Program, King Abdullah University Science and Technology, Thuwal, Saudi Arabia.
Valerio OrlandoBESE Division, KAUST Environmental Epigenetics Program, King Abdullah University Science and Technology, Thuwal, Saudi Arabia.
Emiliana BorrelliCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
N Henriette UhlenhautInstitute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Pierre BaldiInstitute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Jerzy AdamskiGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg Germany; Chair of Experimental Genetics, Technical University of Munich, 85350 Freising-Weihenstephan, Germany. Electronic address: adamski@helmholtz-muenchen.de.
Matthias H TschöpInstitute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technical University of Munich, 80333 Munich, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.
Kristin Eckel-MahanCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address: kristin.l.mahan@uth.tmc.edu.
Paolo Sassone-CorsiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: psc@uci.edu.
Inserm · FRHelmholtz Zentrum München · DEUniversity of California, Irvine · USKing Abdullah University of Science and Technology · SAThe Lundquist Institute · USUniversity of Cambridge · GB
Funding
Bioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4MOrigins of Diet-Induced Circadian Reprogramming and PlasticityR01DK114037 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MAHAN, KRISTIN ECKEL · 2018 to 2022
$1.9MTumor Macroenvironment and the Circadian Metabolic ClockK22CA212045 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI MASRI, SELMA · 2018 to 2020
$607kCommunicating Clocks: Unraveling the nutritional link between the gut microbiome and liver reprogrammingR21DK114652 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSONE-CORSI, PAOLO · 2017 to 2018
$425kThe Circadian Metabolome and its Interplay with Nutritional ChallengesR21DA036408 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSONE-CORSI, PAOLO · 2013 to 2014
$424kRegulation of pre-ribosomal RNA by the Circadian ClockF31GM117942 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CERVANTES, MARLENE · 2018 to 2019
$72kNCI NIH HHS K22 CA212045NIDA NIH HHS R21 DA036408NIDDK NIH HHS R01 DK114037NIDDK NIH HHS R21 DK114652NIGMS NIH HHS F31 GM117942NIGMS NIH HHS R01 GM123558
Abstract
Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve our understanding of health and disease.
Indexed as
MetabolomeAnimalsCircadian ClocksDiet, High-FatEnergy MetabolismLiverMaleMetabolic Networks and PathwaysMetabolomicsMiceMice, Inbred C57BLMuscle, SkeletalPrefrontal CortexSuprachiasmatic NucleusUncoupling Protein 1Ucp1 protein, mouseUncoupling Protein 1circadian rhythmsCircadiOmicsclockhigh-fat dietmetabolismmetabolomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.