Evidence map›Paper›PMID 30193106›Full record

ArticleCell2018

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.

Haiyang Yu, Don W Cleveland

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Functional Characterization of a Familial ALS-Associated MissenseInternational journal of molecular sciences · 2023
    Article
  8. Review
  9. Article
  10. Targeting TANK-binding kinase 1 (TBK1) in cancer.Expert opinion on therapeutic targets · 2020
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Haiyang YuLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Don W ClevelandLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: dcleveland@ucsd.edu.
Ludwig Cancer Research · USUniversity of California San Diego · US

Funding

Determine how loss-of-function of the TBK1 kinase causes age-dependent degeneration in frontotemporal dementiaF32AG059358 · NIA · LUDWIG INSTITUTE FOR CANCER RES LTD · PI YU, HAIYANG · 2018 to 2019
$116k
NIA NIH HHS F32 AG059358
6 · The paper itself

Abstract

Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaApoptosisHumansInflammationMutationProtein Serine-Threonine KinasesReceptor-Interacting Protein Serine-Threonine KinasesProtein Serine-Threonine KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanTBK1 protein, human

Identifiers

PMID30193106
OpenAlexW2890326254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.