ReviewPlant & cell physiology2018
Uncoiling CNLs: Structure/Function Approaches to Understanding CC Domain Function in Plant NLRs.
Review in Plant & cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.Stress biology · 2025Review
- Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat.Nature genetics · 2025Article
- Fine mapping and identification of causal alleles at the Ur-11 locus controlling rust resistance in common bean (Phaseolus vulgaris L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole.EMBO reports · 2024Article
- Comparative analysis on natural variants of fire blight resistance protein FB_MR5 indicates distinct effector recognition mechanisms.Molecules and cells · 2024Article
- The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages.The Plant cell · 2024Article
- A comprehensive review of soybean RNL and TIR domain proteins.Plant molecular biology · 2024Review
- Coping with alpine habitats: genomic insights into the adaptation strategies ofHorticulture research · 2024Article
- Wheat powdery mildew resistance gene Pm13 encodes a mixed lineage kinase domain-like protein.Nature communications · 2024Article
- A plasma membrane nucleotide-binding leucine-rich repeat receptor mediates the recognition of the Ralstonia pseudosolanacearum effector RipY in Nicotiana benthamiana.Plant communications · 2023Article
- Regulation of plant immunity via small RNA-mediated control of NLR expression.Journal of experimental botany · 2023Article
- Taking the lead: NLR immune receptor N-terminal domains execute plant immune responses.The New phytologist · 2023Review
- Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants.Cell death and differentiation · 2023Review
- NLRscape: an atlas of plant NLR proteins.Nucleic acids research · 2023Article
- Identification, characterization, and validation of NBS-encoding genes in grass pea.Frontiers in genetics · 2023Article
- Unmasking the invaders: NLR-mal function in plant defense.Frontiers in plant science · 2023Review
- Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions.Molecules (Basel, Switzerland) · 2022Article
- GLYCINE-RICH RNA-BINDING PROTEIN 7 potentiates effector-triggered immunity through an RNA recognition motif.Plant physiology · 2022Article
- Molecular insights into the biochemical functions and signalling mechanisms of plant NLRs.Molecular plant pathology · 2022Review
- NLR immune receptor RB is differentially targeted by two homologous but functionally distinct effector proteins.Plant communications · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant nucleotide-binding leucine-rich repeat receptors (NLRs) are intracellular pathogen receptors whose N-terminal domains are integral to signal transduction after perception of a pathogen-derived effector protein. The two major plant NLR classes are defined by the presence of either a Toll/interleukin-1 receptor (TIR) or a coiled-coil (CC) domain at their N-terminus (TNLs and CNLs). Our knowledge of how CC domains function in plant CNLs lags behind that of how TIR domains function in plant TNLs. CNLs are the most abundant class of NLRs in monocotyledonous plants, and further research is required to understand the molecular mechanisms of how these domains contribute to disease resistance in cereal crops. Previous studies of CC domains have revealed functional diversity, making categorization difficult, which in turn makes experimental design for assaying function challenging. In this review, we summarize the current understanding of CC domain function in plant CNLs, highlighting the differences in modes of action and structure. To aid experimental design in exploring CC domain function, we present a 'best-practice' guide to designing constructs through use of sequence and secondary structure comparisons and discuss the relevant assays for investigating CC domain function. Finally, we discuss whether using homology modeling is useful to describe putative CC domain function in CNLs through parallels with the functions of previously characterized helical adaptor proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.