ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Genome-targeted enrichment and sequencing of human-infecting Cryptosporidium spp.Nature communications · 2026Article
- Cryptosporidium secreted proteins form a complex layered interface with the host cell.PLoS pathogens · 2026Article
- Prevalence of Cryptosporidium, Giardia, and Entamoeba histolytica in the School-Aged Children of Forcibly Displaced Myanmar Nationals in Bangladesh.The American journal of tropical medicine and hygiene · 2025Article
- Decrease in Incidence of Diarrhea Due to Cryptosporidium in Bangladeshi Children Is Associated With an Increase in Anti-Cryptosporidium Antibody Avidity.The Journal of infectious diseases · 2025Observational
- Cryptosporidium infection and associated factors among diarrheic children under five years of age in Eastern Ethiopia.PLoS neglected tropical diseases · 2025Article
- Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions.Parasite (Paris, France) · 2025Review
- Pairwise Accelerated Failure Time Regression Models for Infectious Disease Transmission in Close-Contact Groups With External Sources of Infection.Statistics in medicine · 2024Article
- Molecular characterization and zoonotic risk assessment ofOne health (Amsterdam, Netherlands) · 2024Article
- Prospective Cohort Study of Cryptosporidium Infection and Shedding in Infants and Their Households.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Diagnosis of protozoa diarrhoea in Campylobacter patients increases markedly with molecular techniques.PLOS global public health · 2023Article
- Oocyst Shedding Dynamics in Children with Cryptosporidiosis: a Prospective Clinical Case Series in Ethiopia.Microbiology spectrum · 2022Article
- Prevalence ofGastroenterology and hepatology from bed to bench · 2022Article
- Occurrence of Cryptosporidium Infection and Associated Risk Factors among HIV-Infected Patients Attending ART Clinics in the Central Region of Ghana.Tropical medicine and infectious disease · 2021Article
- An Update on ZoonoticAnimals : an open access journal from MDPI · 2021Review
- Respiratory cryptosporidiosis in Malawian children with diarrheal disease.PLoS neglected tropical diseases · 2021Observational
- Challenges forGenes · 2021Review
- Transmission of Cryptosporidium Species Among Human and Animal Local Contact Networks in Sub-Saharan Africa: A Multicountry Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- Article
- Household food sources and diarrhoea incidence in poor urban communities, Accra Ghana.PloS one · 2021Article
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCryptosporidium is a leading contributor to diarrheal morbidity and mortality in under-5 children worldwide. As there is no vaccine and no effective drug therapy in young children for this infection, preventing infection is critical. We undertook a pilot case-control study to define the extent of person-to-person transmission of cryptosporidiosis within an urban and a rural community in Bangladesh.
methodsWe enrolled 48 case families with a Cryptosporidium-infected child aged 6-18 months. Controls were age- and sex-matched Cryptosporidium-negative children in 12 households. Children and household members were followed for 8 weeks with weekly illness survey and stool testing with quantitative polymerase chain reaction for Cryptosporidium.
resultsIn the 24 urban case families, the secondary attack rate was 35.8% (19/53) vs 0% (0/11) in controls (P = .018, χ2 test). In contrast, in the 24 rural case families, the secondary attack rate was 7.8% (5/64) vs 0% (0/21) in controls (P = .19, χ2 test). Genotyping by gp60 demonstrated infection with the same subspecies in 5 families, and evidence of transmission in 2. Serologic response to Cryptosporidium infection was associated with younger age, longer duration of infection, and Cryptosporidium hominis gp60_IbA9G3R2 infection.
conclusionsIn the urban site, the high rate of secondary infection and infection with the same subspecies within families suggests that person-to-person transmission is a major source of Cryptosporidium infection for young children living in this region. Molecular genotyping can be applied to determine transmission of Cryptosporidium in endemic regions. Further work is needed to understand the differences in parasite transmissibility and immunity to different genotypes.
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