Evidence map›Paper›PMID 30192777›Full record

ArticlePloS one2018

Associations between health systems capacity and mother-to-child HIV prevention program outcomes in Zambia.

Joan T Price, Benjamin H Chi, Winifreda M Phiri, Helen Ayles, Namwinga Chintu, Roma Chilengi, Jeffrey S A Stringer, Wilbroad Mutale

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joan T PriceSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID 0000-0003-4178-0405
Benjamin H ChiSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Winifreda M PhiriUNC Global Projects Zambia, Lusaka, Zambia.
Helen AylesZambart, Lusaka, Zambia.
Namwinga ChintuSociety for Family Health, Lusaka, Zambia.
Roma ChilengiCenter for Infectious Disease Research in Zambia, Lusaka, Zambia.
Jeffrey S A StringerSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Wilbroad MutaleUniversity of Zambia School of Public Health, Lusaka, Zambia.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UNC Global Women’s Health FellowshipT32HD075731 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2013 to 2024
$2.4M
Mentoring new investigators in PMTCT implementation researchK24AI120796 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Benjamin H. Chi · 2016 to 2026
$1.3M
Validation of a community survey methodology for measuring PMTCT impactR01HD075131 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2013
$903k
A Career Development Award in HIV-Associated Preterm Birth and its PreventionK01TW010857 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PRICE, JOAN · 2017 to 2021
$682k
FIC NIH HHS K01 TW010857NIAID NIH HHS K24 AI120796NIAID NIH HHS P30 AI050410NICHD NIH HHS R01 HD075131NICHD NIH HHS T32 HD075731
6 · The paper itself

Abstract

introductionZambia has made substantial investments in health systems capacity, yet it remains unclear whether improved service quality improves outcomes. We investigated the association between health system capacity and use of prevention of mother-to-child HIV transmission (PMTCT) services in Zambia. MATERIALS AND

methodsWe analyzed data from two studies conducted in rural and semi-urban Lusaka Province in 2014-2015. Health system capacity, our primary exposure, was measured with a validated balanced scorecard approach. Based on WHO building blocks for health systems strengthening, we derived overall and domain-specific facility scores (range: 0-100), with higher scores indicating greater capacity. Our outcome, community-level maternal antiretroviral drug use at 12 months postpartum, was measured via self-report in a large cohort study evaluating PMTCT program impact. Associations between health systems capacity and our outcome were analyzed via linear regression.

resultsAmong 29 facilities, median overall facility score was 72 (IQR:67-74). Median domain scores were: patient satisfaction 75 (IQR 71-78); human resources 85 (IQR:63-87); finance 50 (IQR:50-67); governance 82 (IQR:74-91); service capacity 77 (IQR:68-79); service provision 60 (IQR:52-76). Our programmatic outcome was measured from 804 HIV-infected mothers. Median community-level antiretroviral use at 12 months was 81% (IQR:69-89%). Patient satisfaction was the only domain score significantly associated with 12-month maternal antiretroviral use (β:0.22; p = 0.02). When we excluded the human resources and finance domains, we found a positive association between composite 4-domain facility score and 12-month maternal antiretroviral use in peri-urban but not rural facilities.

conclusionsIn these Zambian health facilities, patient satisfaction was positively associated with maternal antiretroviral 12 months postpartum. The association between overall health system capacity and maternal antiretroviral drug use was stronger in peri-urban versus rural facilities. Additional work is needed to guide strategic investments for improved outcomes in HIV and broader maternal-child health region-wide.

Indexed as

Delivery of Health CareHealth FacilitiesQuality of Health CareAnti-HIV AgentsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalMaternal-Child Health ServicesPregnancyRural PopulationZambiaAnti-HIV Agents

Identifiers

PMID30192777
PMCPMC6128540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.