ArticlePLoS genetics2018
Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Compensatory action of different types of cis-regulatory elements buffers the striped expression of Drosophila pair-rule genes.Development (Cambridge, England) · 2025Article
- Global repression by tailless during segmentation.Developmental biology · 2024Article
- Transcriptional activators in the early Drosophila embryo perform different kinetic roles.Cell systems · 2023Article
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Article
- Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events.Development (Cambridge, England) · 2022Article
- Hunchback prevents notch-induced apoptosis in the serotonergic lineage of Drosophila Melanogaster.Developmental biology · 2022Article
- Molecular competition can shape enhancer activity in theiScience · 2021Article
- Annotating the Insect Regulatory Genome.Insects · 2021Review
- A Mutation in theG3 (Bethesda, Md.) · 2020Article
- Evidence That Runt Acts as a Counter-Repressor of Groucho DuringG3 (Bethesda, Md.) · 2020Article
- Multimodal transcriptional control of pattern formation in embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- On the specificity of gene regulatory networks: How does network co-option affect subsequent evolution?Current topics in developmental biology · 2020Review
- An Atlas of Transcription Factors Expressed in Male Pupal Terminalia ofG3 (Bethesda, Md.) · 2019Article
- Causal Gene Regulatory Network Modeling and Genomics: Second-Generation Challenges.Journal of computational biology : a journal of computational molecular cell biology · 2019Article
- Article
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Authors and funding
10 authors.
Funding
Abstract
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its target genes, even-skipped (eve). While Hunchback directly represses the eve stripe 3+7 enhancer, we found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression. We also found evidence that Caudal binding sites are responsible for counter-repression, and that this interaction may be a conserved feature of eve stripe 2 enhancers. Our results alter the textbook view of eve stripe 2 regulation wherein Hb is described as a direct activator. Instead, to generate stripe 2, Hunchback repression must be counteracted. We discuss how counter-repression may influence eve stripe 2 regulation and evolution.
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