ArticleThe journal of physical chemistry letters2018
Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models.
Article in The journal of physical chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The physicochemical design, structure and permeability of the JCVI-syn3A minimal cell membrane.Nature communications · 2026Article
- Asymmetry and heterogeneity in the plasma membrane.Biophysical journal · 2026Article
- Review
- Measuring the Transmembrane Registration of Lipid Domains in Droplet Interface Bilayers through Tensiometry.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Role of cholesterol flip-flop in oxidized lipid bilayers.Biophysical journal · 2021Article
- Capturing Membrane Phase Separation by Dual Resolution Molecular Dynamics Simulations.Journal of chemical theory and computation · 2021Article
- Nonconverged Constraints Cause Artificial Temperature Gradients in Lipid Bilayer Simulations.The journal of physical chemistry. B · 2021Article
- Long chain sphingomyelin depletes cholesterol from the cytoplasmic leaflet in asymmetric lipid membranes.RSC advances · 2021Article
- Lateral heterogeneity and domain formation in cellular membranes.Chemistry and physics of lipids · 2020Article
- Capturing Biologically Complex Tissue-Specific Membranes at Different Levels of Compositional Complexity.The journal of physical chemistry. B · 2020Article
- Dual Resolution Membrane Simulations Using Virtual Sites.The journal of physical chemistry. B · 2020Article
- Inserting Small Molecules across Membrane Mixtures: Insight from the Potential of Mean Force.Biophysical journal · 2020Article
- Real-time cholesterol sorting in Plasmodium falciparum-erythrocytes as revealed by 3D label-free imaging.Scientific reports · 2020Article
- Interleaflet Coupling of Lipid Nanodomains - Insights FromFrontiers in cell and developmental biology · 2020Review
- HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly.Science advances · 2019Article
- Nanoscale dynamics of cholesterol in the cell membrane.The Journal of biological chemistry · 2019Article
- Recent Advances in Coarse-Grained Models for Biomolecules and Their Applications.International journal of molecular sciences · 2019Review
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coupling of cholesterol-enriched domains. We show that the cholesterol density correlation between the leaflets of an average mammalian plasma membrane is significantly reduced by suppressing interleaflet cholesterol population. Our results suggest an amplifying role of cholesterol in signal transduction across the leaflets.
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Registered trials
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