Evidence map›Paper›PMID 30192394›Full record

ArticleAlcoholism, clinical and experimental research2018

Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis.

Li-Shin Huang, Jason J Yuen, Michael J Trites, Amit Saha, Caleb T Epps, Yungying Hu, Sarahjean Kerolle, Seung-Ah Lee, Hongfeng Jiang, Ira J Goldberg and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Li-Shin HuangDepartment of Medicine, Columbia University, New York, New York.
Jason J YuenDepartment of Medicine, Columbia University, New York, New York.
Michael J TritesDepartment of Physiology, University of Alberta, Edmonton, AB, Canada.
Amit SahaDepartment of Medicine, Columbia University, New York, New York.
Caleb T EppsDepartment of Medicine, Columbia University, New York, New York.
Yungying HuDepartment of Medicine, New York University Langone Medical Center, New York, New York.
Sarahjean KerolleDepartment of Medicine, Columbia University, New York, New York.
Seung-Ah LeeDepartment of Medicine, Columbia University, New York, New York.
Hongfeng JiangDepartment of Medicine, Columbia University, New York, New York.
Ira J GoldbergDepartment of Medicine, New York University Langone Medical Center, New York, New York.
William S BlanerDepartment of Medicine, Columbia University, New York, New York.
Robin D ClugstonDepartment of Physiology, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-0264-9594
Columbia University · USNYU Langone Health · USUniversity of Alberta · CA

Funding

Postprandial Vitamin AR01DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2004 to 2023
$7.0M
Pathways of Tissue Lipid UptakeR01HL045095 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABUMRAD, NADA A., GOLDBERG, IRA J · 1991 to 2024
$6.9M
EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITYR37HL045095 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDBERG, IRA J · 2000 to 2009
$4.6M
Vitamin A Homeostasis: Retinyl Ester StoresR01DK101251 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S, HARRISON, EARL HOWARD · 2016 to 2018
$1.4M
Vitamin A Storage and MetabolismR01DK079221 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2007 to 2010
$1.3M
Nutritional and Hormonal Pathways for Reduction of ApoB-lipoproteinsR21HL112233 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDBERG, IRA J, HUANG, LI-SHIN · 2012 to 2013
$430k
Alcohol Intake and Hepatic Fat MetabolismR21AA020561 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, LI-SHIN · 2011 to 2012
$420k
Alcohol Consumption and Brown Adipose TissueR21AA021336 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2013 to 2014
$414k
Alcoholic liver disease and its association with hepatic vitamin A homeostasisK99AA022652 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLUGSTON, ROBIN D · 2014 to 2015
$241k
Canadian Institutes of Health Research (CIHR)Canadian Natural Sciences and Engineering Research Council (NSERC), Alexander Graham Bell Canada Graduate Scholarship-DoctoralInstitute of Nutrition, Metabolism and Diabetes PJT 156226NHLBI NIH HHS R01 HL045095NHLBI NIH HHS R21 HL112233NHLBI NIH HHS R37 HL045095NIAAA NIH HHS K99 AA022652NIAAA NIH HHS R21 AA020561NIAAA NIH HHS R21 AA021336NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK079221NIDDK NIH HHS R01 DK101251
6 · The paper itself

Abstract

backgroundThe first stage of alcoholic liver disease is hepatic steatosis. While alcohol is known to profoundly impact hepatic lipid metabolism, gaps in our knowledge remain regarding the mechanisms leading to alcohol-induced hepatic triglyceride (TG) accumulation. As the sole enzymes catalyzing the final step in TG synthesis, diacylglycerol O-acyltransferase (DGAT) 1 and 2 are potentially important contributors to alcoholic steatosis. Our goal was to study the effects of dietary fat content on alcohol-induced hepatic TG accumulation, and the relative contribution of DGAT1 and DGAT2 to alcoholic steatosis.

methodsThese studies were carried out in wild-type (WT) mice fed alcohol-containing high-fat or low-fat formulations of Lieber-DeCarli liquid diets, as well as follow-up studies in Dgat1

resultsA direct comparison of the low-fat and high-fat liquid diet in WT mice revealed surprisingly similar levels of alcoholic steatosis, although there were underlying differences in the pattern of hepatic lipid accumulation and expression of genes involved in hepatic lipid metabolism. Follow-up studies in Dgat1

conclusionsDietary macronutrient composition influences the relative contribution of DGAT1 and DGAT2 to alcoholic steatosis, such that in the context of alcohol and a high-fat diet, DGAT1 predominates.

Indexed as

DietNutrientsAnimalsDiacylglycerol O-AcyltransferaseDietary FatsDiet, Fat-RestrictedFatty Liver, AlcoholicGene Expression Regulation, EnzymologicLipid MetabolismLiverMaleMiceMice, Inbred C57BLMice, KnockoutTriglyceridesDgat1 protein, mouseDGAT2 protein, mouseDiacylglycerol O-AcyltransferaseDietary FatsNutrientsTriglyceridesAlcoholDGATLiverSteatosisTriglyceride

Identifiers

PMID30192394
PMCPMC6286229
OpenAlexW2890213068

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.