Evidence map›Paper›PMID 30192378›Full record

ArticleJournal of clinical pharmacology2019

A Phase 1, Multiple-Dose Study of Vedolizumab in Japanese Patients With Ulcerative Colitis.

Kiyonori Kobayashi, Yasuo Suzuki, Kenji Watanabe, Kazunori Oda, Miyuki Mukae, Akihiro Yamada, Hirokazu Yamagami, Akira Nishimura, Hiroyuki Okamoto

Open access · hybridAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Kiyonori KobayashiDepartment of Gastroenterology, Kitasato University East Hospital, Sagamihara City, Kanagawa, Japan.
Yasuo SuzukiDepartment of Internal Medicine, Toho University Medical Center Sakura Hospital, Sakura City, Chiba, Japan.
Kenji WatanabeDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Kazunori OdaRegenerative Medicine Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Miyuki MukaeDepartment of Gastroenterology, Kitasato University East Hospital, Sagamihara City, Kanagawa, Japan.
Akihiro YamadaDepartment of Internal Medicine, Toho University Medical Center Sakura Hospital, Sakura City, Chiba, Japan.
Hirokazu YamagamiDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Akira NishimuraTakeda Development Center, Takeda Pharmaceutical Company Limited, Chuo-ku, Osaka, Japan.
Hiroyuki OkamotoTakeda Development Center, Takeda Pharmaceutical Company Limited, Chuo-ku, Osaka, Japan.
Takeda (Japan) · JPToho University Medical Center Sakura Hospital · JPHyogo Medical University · JPKitasato University East Hospital · JPKitasato University Hospital · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although previous studies have shown that patients with ulcerative colitis may benefit from treatment with vedolizumab, a humanized monoclonal antibody targeting the α

Indexed as

AdultAntibodies, Monoclonal, HumanizedAsian PeopleColitis, UlcerativeDose-Response Relationship, DrugFemaleGastrointestinal AgentsHumansMaleMiddle AgedAntibodies, Monoclonal, HumanizedGastrointestinal Agentsvedolizumabinflammatory bowel diseaseJapaneseulcerative colitisvedolizumab

Identifiers

PMID30192378
PMCPMC6718004
OpenAlexW2890293380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.