Evidence map›Paper›PMID 30191749›Full record

ArticleGlobal health action2018

Attrition among HIV positive children enrolled under integrated HIV care programme in Myanmar: 12 years cohort analysis.

Aung Chan Minn, Nang Thu Thu Kyaw, Thet Ko Aung, Ohn Mar Mon, Thurain Htun, Myo Minn Oo, July Moe, Aye Aye Mon, Srinath Satyanarayana, Htun Nyunt Oo

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Global health action, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04712058 (A Multicenter Clinical Trial to Evaluate the Feasibility and Outcome of Same-day Antiretroviral Therapy With Bictegravir/Emtricitabine/Tenofovir Alafenamide), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04712058 naunknown statusnot on this mapstarted 2021, after this paper: background citation

A Multicenter Clinical Trial to Evaluate the Feasibility and Outcome of Same-day Antiretroviral Therapy With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/F/TAF) Among Patients Testing Positive by HIV Confirmatory Tests

TypeinterventionalSponsorNational Taiwan University HospitalRan2021 to 2023Enrolled200ConditionsHIV InfectionsArmsBictegravir / Emtricitabine / Tenofovir Alafenamide Oral Tablet [Biktarvy]
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Aung Chan Minna International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.
Nang Thu Thu Kyawa International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.ORCID 0000-0002-4849-579X
Thet Ko Aunga International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.ORCID 0000-0002-6222-7994
Ohn Mar Monb Ministry of Health and Sports (MOHS) , 550 bedded Children Hospital , Mandalay , Myanmar.
Thurain Htuna International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.
Myo Minn Ooa International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.ORCID 0000-0003-4089-016X
July Moea International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.
Aye Aye Mona International Union Against Tuberculosis and Lung Disease , Myanmar country office , Mandalay , Myanmar.
Srinath Satyanarayanac Center for Operational Research , International Union Against Tuberculosis and Lung Diseases , Paris , France.
Htun Nyunt Ood National AIDS Program, Department of Public Health , Ministry of Health and Sports , Nay Pyi Taw , Myanmar.ORCID 0000-0003-4089-016X
Ministry of Health and Sports · MMInternational Union Against Tuberculosis and Lung Disease · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Myanmar, HIV seropositive children are being enrolled in an integrated HIV care (IHC) Program for HIV treatment and care since 2005.

objectivesTo assess the: (a) attrition (death or loss-to-follow-up) rates among children (aged ≥ 18 months to < 15 years) enrolled into the programme before and after initiation of anti-retroviral therapy (ART) (pre-ART and ART periods); (b) demographic and clinical factors associated with attrition during these two periods.

methodsChildren enrolled in IHC Programme and their status (death, lost to follow-up, regular follow-up or transferred out) was assessed as on 30 June 2017. Attrition rates (per 100 person-years) at pre - ART and ART periods were calculated and the association between demographic and clinical characteristics with attrition was assessed using Cox proportional hazards model.

resultsAmong 2,736 children enrolled, pre-ART attrition rate was 19 per 100 person-years of follow-up (95% CI: 17-21) and ART attrition rate was 4 per 100 person-years of follow-up (95% CI: 3-4) with higher levels during the initial few months of enrolment. The 36-month retention rates during pre-ART period was 75% (95% CI: 72-78) and during ART period was 87% (95% CI: 86-88). The children 'at enrolment' with relatively lower levels of haemoglobin, immune deficiency, underweight for age, higher WHO clinical stages, presence of hepatitis B infection had higher hazards of attrition in both periods.

conclusionThe attrition rates are high particularly among children with relatively poorer clinical, nutritional profiles at enrolment. The study suggests the urgent need for improving adherence counselling especially during the initial few months of enrolment and early ART initiation.

Indexed as

Lost to Follow-UpAdolescentAnti-HIV AgentsCD4 Lymphocyte CountChildChild, PreschoolCohort StudiesFemaleHealth StatusHIV InfectionsHumansInfantMaleMyanmarProportional Hazards ModelsSocioeconomic FactorsAnti-HIV AgentsAttritionchildrendeathHIVlost to follow upretentionSORT-IT

Identifiers

PMID30191749
PMCPMC6136349
OpenAlexW2891341317

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.