ArticleCancer medicine2018
Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.
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Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
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- Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research.United European gastroenterology journal · 2020Observational
- Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins.Gastroenterology research and practice · 2020Article
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- Bioinformatics analysis of microarray data to identify the candidate biomarkers of lung adenocarcinoma.PeerJ · 2019Article
- Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.Cancer medicine · 2018Article
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Authors and funding
62 authors at 20 institutions in 5 countries.
Sophie K M HeinrichsInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Timo HessInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Jessica BeckerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Lutz HamannInstitute for Microbiology and Hygiene, Charité University Medical Center Berlin, Berlin, Germany.
Yogesh K VashistDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas SchmidtDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7166-3675
Hakan AlakusDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Iurii KrasniukDepartment of General and Visceral Surgery, Municipal Hospital Solingen, Solingen, Germany.
Aksana HöblingerDepartment of Internal Medicine I, Community Hospital Mittelrhein, Koblenz, Germany.
Philipp LingohrDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Bonn, Germany.
Monika LudwigAssociation for Oncological Studies (Gefos), Dortmund, Germany.
Alexander F HagelDepartment of Medicine I, Gastroenterology and Interventional Endoscopy, University of Erlangen, Erlangen, Germany.
Claus W SchildbergDepartment of Surgery, University of Erlangen, Erlangen, Germany.
Lothar VeitsInstitute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
Ugne GyvyteDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Katharina WeiseInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Vitalia SchüllerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Anne C BöhmerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Julia SchröderInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Jan GehlenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Nicole KreuserDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Sebastian HoferDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Hauke LangDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Florian LordickUniversity Cancer Center Leipzig (UCCL), University Hospital of Leipzig, Leipzig, Germany.
Peter MalfertheinerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Markus MoehlerFirst Medical Clinic and Policlinic, University Medical Center, University of Mainz, Mainz, Germany.
Oliver PechDepartment of Gastroenterology and Interventional Endoscopy, St. John of God Hospital, Regensburg, Germany.
Nikolaos VassosDepartment of Surgery, University of Erlangen, Erlangen, Germany.
Ernst RodermannAssociation of Medical Practices in Hematology and Internal Oncology, Troisdorf, Germany.
Jakob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martin KruschewskiDepartment of General and Visceral Surgery, Hospital Frankfurt Oder, Frankfurt Oder, Germany.
Katja OttDepartment of General, Visceral and Thorax Surgery, RoMed Hospital Rosenheim, Rosenheim, Germany.
Ralf R SchumannInstitute for Microbiology and Hygiene, Charité University Medical Center Berlin, Berlin, Germany.
Michael ViethInstitute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
Elisabeth MangoldInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Evita GasenkoInstitute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia.
Limas KupcinskasDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Peter GrimmingerDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Luis BujandaCIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Federico SopeñaCIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Jesús EspinelDepartment of Gastroenterology, Complejo Hospitalario, León, Spain.
Concha ThomsonDepartment of Gastroenterology, Hospital Obispo Polanco, Teruel, Spain.
Ángeles Pérez-AísaDepartment of Gastroenterology, Hospital del Sol, Marbella, Spain.
Rafael CampoDepartment of Gastroenterology, Hospital Parc Tauli, Sabadell, Spain.
Fernando GeijoDepartment of Gastroenterology, Hospital Clínico Universitario, Salamanca, Spain.
Daniela ColletteAssociation of Medical Practices in Hematology and Oncology, Dortmund, Germany.
Christiane BrunsDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Katharina MesserleDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Ines GockelDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Hans LippertAn-Institute for Quality Control in Surgery, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Karsten RidwelskiAn-Institute for Quality Control in Surgery, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Angel LanasCIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
Gisela KellerInstitute of Pathology, Technical University of Munich, Munich, Germany.
Michael KnappInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Marcis LejaInstitute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia.
Juozas KupcinskasDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Maria A García-GonzálezInstituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.
Marino VeneritoDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Johannes SchumacherInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0001-9217-6457
University of Bonn · DEJohannes Gutenberg University Mainz · DEUniversity Hospital Magdeburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DELithuanian University of Health Sciences · LTUniversity Hospital Leipzig · DEUniversity of Cologne · DEBayreuth Medical Center · DECentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESCharité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DERiga East University Hospital · LVUniversität Hamburg · DEAtos Medical · DEComplejo Hospitalario de Salamanca · ESFeuerwehr Dortmund · DEGemeinschaftsklinikum Mittelrhein · DEGoethe University Frankfurt · DEHeidelberg University · DEHospital Clínico Universitario Lozano Blesa · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 × 10
Indexed as
AcyltransferasesAntigens, NeoplasmCase-Control StudiesChromosome MappingChromosomes, Human, Pair 5Chromosomes, Human, Pair 8FemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGPI-Linked ProteinsHumansMaleMembrane ProteinsAcyltransferasesAntigens, NeoplasmGPI-Linked ProteinsMBOAT7 protein, humanMembrane ProteinsNeoplasm ProteinsPSCA protein, humanPTGER4 protein, humanReceptors, Prostaglandin E, EP4 SubtypeeQTL studygene expressiongenetic association studystomach neoplasms
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