Evidence map›Paper›PMID 30191642›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Enantioselective Functionalization of Enamides at the β-Carbon Center with Indoles.

Mirza A Saputra, Binod Nepal, Nitin S Dange, Pu Du, Frank R Fronczek, Revati Kumar, Rendy Kartika

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mirza A SaputraDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Binod NepalDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Nitin S DangeDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Pu DuDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Frank R FronczekDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Revati KumarDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.
Rendy KartikaDepartment of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803, USA.ORCID 0000-0002-2042-2812
Louisiana State University · US

Funding

New Synthetic Chemistries Enabled by Oxyallyl and 2-Aminoallyl CationsR01GM127649 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KARTIKA, RENDY GREGORY · 2018 to 2022
$1.4M
NIGMS NIH HHS R01 GM127649NIGMS NIH HHS R01GM127649
6 · The paper itself

Abstract

We report an enantioconvergent approach for the functionalization of enamides at the β-carbon atom, which involves a chiral Brønsted acid induced tautomerization of 2-amidoallyl into 1-amidoallyl cations. These putative reactive intermediates were produced by ionization of racemic α-hydroxy enamides with a chiral Brønsted acid and captured with substituted indoles in a highly regio- and enantioselective manner.

Indexed as

Allyl CompoundsAmidesCarbonCatalysisCationsIndolesStereoisomerismAllyl CompoundsAmidesCarbonCationsIndoles2-amidoallyl cationsasymmetric catalysisBrønsted acidsindolestautomerization

Identifiers

PMID30191642
PMCPMC6407611
OpenAlexW2889710775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.