ArticleJournal of cancer survivorship : research and practice2018
The effect of comorbidities on outcomes in colorectal cancer survivors: a population-based cohort study.
Article in Journal of cancer survivorship : research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Pooled it
- Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness.The international journal of behavioral nutrition and physical activity · 2020Pooled it
- Patient-reported outcomes as predictors of survival in patients with bowel cancer: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- Patterns of Multimorbidity among Older Adults with Colorectal Cancer Living in Puerto Rico.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Article
- General Principles of Risk Mitigation before Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Comparative Effectiveness of Laparoscopic versus Open Colectomy on 5-Year Overall Survival in Non-Metastatic Colon Cancer: A Target Trial Emulation Study Using Retrospective Cohort Data from a Cancer Registry.Clinical epidemiology · 2026Article
- Perioperative cognitive dysfunction in bladder cancer patients, causal factors, and possible interventions.Frontiers in medicine · 2026Review
- Progress on the regulation of colorectal cancer and cardio-oncology by the gut microbiota and nutrients.Frontiers in immunology · 2026Review
- Are Calculated Immune Markers with or Without Comorbidities Good Predictors of Colorectal Cancer Survival? The Results of a Longitudinal Study.Medical sciences (Basel, Switzerland) · 2025Observational
- Sex differences in the impact of multimorbidity on long-term mortality for patients with colorectal cancer: a population registry-based cohort study.Journal of public health (Oxford, England) · 2025Article
- Challenges oncologists face when caring for hispanics living in puerto rico with colorectal cancer and multiple chronic conditions.BMC cancer · 2025Article
- Does surgeon or hospital volume influence outcome in dedicated colorectal units?-A Viennese perspective.Wiener klinische Wochenschrift · 2025Article
- Variation in colorectal cancer treatment and outcomes in Scotland: real world evidence from national linked administrative health data.International journal of population data science · 2024Article
- SCORE: a randomised controlled trial evaluating shared care (general practitioner and oncologist) follow-up compared to usual oncologist follow-up for survivors of colorectal cancer.EClinicalMedicine · 2023Article
- Physical Activity among Colorectal Cancer Patients and Survivors in Egypt.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Variations in colorectal cancer pattern of care by age and comorbidity in South Australia.Cancer medicine · 2023Article
- Causes of death among early-onset colorectal cancer population in the United States: a large population-based study.Frontiers in oncology · 2023Article
- Multimorbidity in people living with and beyond cancer: a scoping review.American journal of cancer research · 2023Article
- Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan's Cancer Registry Database.Clinical Medicine Insights. Oncology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo examine the prevalence of comorbidities and the association of these comorbidities with demographics, tumor characteristics, treatments received, overall survival, and causes of death in a population-based cohort of colorectal cancer (CRC) patients.
methodsAdult patients with stage I-III CRC diagnosed between 2004 and 2015 were included. Comorbidities were captured using Charlson comorbidity index. Causes of death were categorized using International Classification of Diseases, tenth revision codes. Patients were categorized into five mutually exclusive comorbid groups (cardiovascular disease alone, diabetes alone, cardiovascular disease plus diabetes, other comorbidities, or no comorbidities). Data were analyzed using descriptive statistics, Kaplan-Meier survival analyses, and Cox proportional hazards models.
resultsThere were 12,265 patients. Mean follow-up was 3.8 years. Approximately one third of patients had a least one comorbidity, with cardiovascular disease and diabetes being most common. There were statistically significant differences across comorbid groups on treatments received and overall survival. Those with comorbidity had lower odds of treatment and greater risk of death than those with no comorbidity. Those with cardiovascular disease plus diabetes fared the worst for prognosis (median overall survival 3.3 [2.8-3.7] years; adjusted HR for death, 2.27, 95% CI 2.0-2.6, p < .001). Cardiovascular disease was the most common cause of non-CRC death.
conclusionsCRC patients with comorbidity received curative intent treatment less frequently and experienced worse outcomes than patients with no comorbidity. Cardiovascular disease was the most common cause of non-cancer death. IMPLICATIONS FOR CANCER SURVIVORS: Management of comorbidities, including healthy lifestyle coaching, at diagnosis and into survivorship is an important component of cancer care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.