ArticleJournal of the Association for Research in Otolaryngology : JARO2018
Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Comparing Bilateral and Single-Sided Deaf Cochlear Implant Recipients in a Novel Speech-in-Noise and Localization Task.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- Interaural time difference sensitivity under binaural cochlear implant stimulation persists at high pulse rates up to 900 pps.Scientific reports · 2023Article
- Temporal hyper-precision of brainstem neurons alters spatial sensitivity of binaural auditory processing with cochlear implants.Frontiers in neuroscience · 2022Article
- [Communication sound recognition and response modification in the secondary auditory cortex of female mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Rate and Temporal Coding of Regular and Irregular Pulse Trains in Auditory Midbrain of Normal-Hearing and Cochlear-Implanted Rabbits.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Improving Interaural Time Difference Sensitivity Using Short Inter-pulse Intervals with Amplitude-Modulated Pulse Trains in Bilateral Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Temporal-pitch sensitivity in electric hearing with amplitude modulation and inserted pulses with short inter-pulse intervals.The Journal of the Acoustical Society of America · 2020Article
- Paired measurements of cochlear function and hair cell count in Dutch-belted rabbits with noise-induced hearing loss.Hearing research · 2020Article
- Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Introducing Short Interpulse Intervals in High-Rate Pulse Trains Enhances Binaural Timing Sensitivity in Electric Hearing.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants in Unanesthetized Rabbits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Effects of Monaural Temporal Electrode Asynchrony and Channel Interactions in Bilateral and Unilateral Cochlear-Implant Stimulation.Trends in hearingArticle
- Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints.Trends in hearingReview
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Bilateral cochlear implant (CI) users have poor perceptual sensitivity to interaural time differences (ITDs), which limits their ability to localize sounds and understand speech in noisy environments. This is especially true for high-rate (> 300 pps) periodic pulse trains, which are used as carriers in CI processors. Here, we investigate a novel stimulation strategy in which extra pulses are added to high-rate periodic pulse trains to introduce short inter-pulse intervals (SIPIs). We hypothesized that SIPIs can improve neural ITD sensitivity similarly to the effect observed by randomly jittering IPIs (Hancock et al., J. Neurophysiol. 108:714-28, 2012). To test this hypothesis, we measured ITD sensitivity of single units in the inferior colliculus (IC) of unanesthetized rabbits with bilateral CIs. Introducing SIPIs into high-rate pulse trains significantly increased firing rates for ~ 60 % of IC neurons, and the extra spikes tended to be synchronized to the SIPIs. The additional firings produced by SIPIs uncovered latent ITD sensitivity that was comparable to that observed with low-rate pulse trains. In some neurons, high spontaneous firing rates masked the ITD sensitivity introduced by SIPIs. ITD sensitivity in these neurons could be revealed by emphasizing stimulus-synchronized spikes with a coincidence detection analysis. Overall, these results with SIPIs are consistent with the effects observed previously with jittered pulse trains, with the added benefit of retaining control over the timing and number of SIPIs. A novel CI processing strategy could incorporate SIPIs by inserting them at selected times to high-rate pulse train carriers. Such a strategy could potentially improve ITD perception without degrading speech intelligibility and thereby improve outcomes for bilateral CI users.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.