Evidence map›Paper›PMID 30191381›Full record

ArticleMolecular neurobiology2019

Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis.

Milena Pinto, Uma D Vempati, Francisca Diaz, Susana Peralta, Carlos T Moraes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. RSC advances · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Milena PintoDepartment of Neurology, Miller School of Medicine Miami, University of Miami, 1420 NW 9th Avenue, TSL Building, Rm. 231, Miami, FL, 33136, USA. mpinto@med.miami.edu.ORCID http://orcid.org/0000-0001-9202-1527
Uma D VempatiDepartment of Neurology, Miller School of Medicine Miami, University of Miami, 1420 NW 9th Avenue, TSL Building, Rm. 231, Miami, FL, 33136, USA.
Francisca DiazDepartment of Neurology, Miller School of Medicine Miami, University of Miami, 1420 NW 9th Avenue, TSL Building, Rm. 231, Miami, FL, 33136, USA.
Susana PeraltaDepartment of Neurology, Miller School of Medicine Miami, University of Miami, 1420 NW 9th Avenue, TSL Building, Rm. 231, Miami, FL, 33136, USA.
Carlos T MoraesDepartment of Neurology, Miller School of Medicine Miami, University of Miami, 1420 NW 9th Avenue, TSL Building, Rm. 231, Miami, FL, 33136, USA. cmoraes@med.miami.edu.
University of Miami · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
SETTING THE STAGE FOR REPLACEMENT OF MITOCHONDRIAL GENESR01EY010804 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 1995 to 2025
$9.4M
Cellular and Molecular Consequences of Respiratory Chain Defects in NeuronsR01NS079965 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2012 to 2023
$3.9M
Mitochondrial Dysfunction in Neurodegeneration and Compensatory ApproachesR01AG036871 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2010 to 2020
$3.3M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY010804NIA NIH HHS R01 AG036871NIH HHS 1R01AG036871NIH HHS 1R01NS079965NIH HHS 5R01EY010804NINDS NIH HHS R01 NS079965
6 · The paper itself

Abstract

Cytochrome c (Cyt c), a heme-containing mitochondrial protein, has a critical function in both respiration and apoptosis. Consistent with these vital functions, somatic Cyt c mouse knockout is embryonic lethal. In order to investigate the sensitivity of postnatal neurons to Cyt c depletion, we developed a neuron-specific conditional knockout model. Neuron-specific Cyt c KO mouse (nCytc

Indexed as

ApoptosisGene DeletionOxidative PhosphorylationAnimalsCytochromes cElectron Transport Complex IVInflammationLocomotionMice, KnockoutMitochondriaNerve DegenerationNeuronsOxidative StressPhenotypeProsencephalonCytochromes cElectron Transport Complex IVConditional knock outCytochrome cMitochondrial dysfunction

Identifiers

PMID30191381
PMCPMC6942697
OpenAlexW2890649851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.